- ►pnas.org JM Wenzlau, K Juhl, L Yu, O Moua, SA … - Proceedings of the …, 2007 - National Acad Sciences Type 1 diabetes (T1D) results from progressive loss of pancreatic islet mass through autoimmunity
targeted at a diverse, yet limited, series of molecules that are expressed in the pancreatic β
cell. Identification of these molecular targets provides insight into the pathogenic process, ... Cited by 91 - Related articles - BL Direct - All 6 versions
R Spolski, M Kashyap, C Robinson, Z Yu, … - Proceedings of the …, 2008 - National Acad Sciences IL-21 is a pleiotropic type I cytokine that shares the common cytokine receptor γ chain and plays
important roles for normal Ig production, terminal B cell differentiation to plasma cells, and Th17
differentiation. IL-21 is elevated in several autoimmune diseases, and blocking its action ... Cited by 21 - Related articles - All 8 versions
- ►diabetesjournals.org E Akirav, JA Kushner, KC Herold - Diabetes, 2008 - Am Diabetes Assoc RESULTS— The loss of β-cells that characterizes type 1 diabetes reflects the net effects of destruction
and regeneration. These processes have been examined in the nonobese diabetic (NOD)
mouse; uncertainty remains about β-cell dynamics in humans. Islet inflammation ... Cited by 10 - Related articles - All 4 versions
NS Hamblet, W Shi, AI Vinik, DA Taylor-Fishwick - Pancreas, 2008 - journals.lww.com Copyright @ Lippincott Williams & Wilkins. Unauthorized reproduction of this article is
prohibited. ... The Reg Family Member INGAP Is a Marker of Endocrine ... Natasha S.
Hamblet, PhD,* Wenjing Shi, MS,* Aaron I. Vinik, MD,*Þ and David A. Taylor-Fishwick, ... Cited by 7 - Related articles - BL Direct - All 2 versions
- ►jhc.org DA Taylor-Fishwick, A Bowman, MC … - … of Histochemistry and …, 2008 - Histochemical Soc DIABETES IS FUNDAMENTALLY a failure of functional β-cell mass (Bell and Polonsky 2001
Go ). Therefore, a curative therapy for diabetes would encompass improved β-cell function
and/or replacement of the functional β-cell compartment. Replacement strategies include ... Cited by 2 - Related articles - BL Direct - All 4 versions
JM Wenzlau, JC Hutton, HW Davidson - Current Opinion in …, 2008 - journals.lww.com Recent findings: Both type 1 diabetes and type 2 diabetes are associated with islet functional
failure and both diseases may be linked to stress responses and changes in the secretory
pathway, which lead to cell apoptosis and thus directly to reduction of β-cell mass or ... Cited by 2 - Related articles - All 3 versions
P Gao, Y Jiao, Q Xiong, CY Wang, I Gerling, … - Current …, 2008 - pubmedcentral.nih.gov A systematic study has been conducted of all available reports in PubMed and OMIM (Online
Mendelian Inheritance in Man) to examine the genetic and molecular basis of quantitative genetic
loci (QTL) of diabetes with the main focus on genes and polymorphisms. The major ... Related articles - All 4 versions
W Cui, K De Jesus, H Zhao, S Takasawa, B … - Free Radical …, 2009 - informahealthcare.com Regenerating gene (Reg) family protein Reg3α is normally expressed in pancreatic acinar and
endocrine cells. In order to explore its effect on islet β-cell replication, insulinoma MIN6 cells
were stably transfected with murine Reg3α cDNA. Determined using real-time PCR and ... Related articles - All 4 versions
E Akirav, JA Kushner, KC Herold - Diabetes, 2008 - Am Diabetes Assoc Studies largely done in nonobese diabetic (NOD) mice have described a linear loss of -cell mass
from the time of initiation of insulitis through presentation with hyperglycemia and afterward until
there is complete loss of -cells (1,2). Results from the Diabetes Prevention Trial-1 (DPT-1) ...
