- ►pnas.org AM Ruschak, AD Miranker - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences A central component of a number of degenerative diseases is the deposition of
protein as amyloid fibers. Self-assembly of amyloid occurs by a
nucleation-dependent mechanism that gives rise to a characteristic ... Cited by 18 - Related articles - BL Direct - All 10 versions
MR Hayden, JR Sowers - Antioxidants & Redox Signaling, 2007 - liebertonline.com T YPE 2 DIABETES mellitus (T2DM) has reached pandemic proportions, and current
predictions are that this trend will continue, at least in the near future (1,
71). Even though there has been a vast amount of new information and treat- ... Cited by 18 - Related articles - BL Direct - All 6 versions
JJW Wiltzius, SA Sievers, MR Sawaya, D … - Protein Science: A Publication of the Protein Society, 2008 - pubmedcentral.nih.gov Islet amyloid polypeptide (IAPP, also called amylin) is associated with type II
diabetes, a disease that has increased over the past two decades and now
afflicts an estimated 20 million people in America and 100 million ... Cited by 16 - Related articles - All 6 versions
P Marchetti, F Dotta, D Lauro, F Purrello - Regulatory Peptides, 2008 - Elsevier Type 2 diabetes is the most common form of diabetes in humans. It results from a
combination of factors that impair beta-cell function and tissue insulin
sensitivity. However, growing evidence is showing that the beta-cell is ... Cited by 14 - Related articles - All 3 versions
B Ahrén, MS Winzell, N Wierup, F Sundler, B … - Regulatory Peptides, 2007 - Elsevier Inhibition of dipeptidyl peptidase-4 (DPP-4) is currently explored as a novel
therapy of type 2 diabetes. The strategy has been shown to improve glycemia in
most, but not all, rodent forms of glucose intolerance. In this study, we ... Cited by 12 - Related articles - All 4 versions
A Masad, L Hayes, BJ Tabner, S Turnbull, LJ … - FEBS letters, 2007 - Elsevier Amyloid deposits derived from the amylin peptide accumulate within pancreatic
islet β-cells in most cases of type-2 diabetes mellitus (T2Dm). Human amylin
'oligomers' are toxic to these cells. Using two different experimental ... Cited by 6 - Related articles - All 6 versions
- ►endojournals.org X Huang, DJ Moore, RJ Ketchum, CS … - Endocrine Reviews, 2008 - Endocrine Soc Although type 1 diabetes cannot be prevented or reversed, replacement of insulin
production by transplantation of the pancreas or pancreatic islets represents a
definitive solution. At present, transplantation can restore euglycemia, ... Cited by 5 - Related articles - All 4 versions
- ►diabetesjournals.org S Zhang, H Liu, H Yu, GJS Cooper - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS— We measured responses to hA in isolated mouse
islets and two insulinoma cell lines, wherein we measured Fas/Fas ligand (FasL)
and Fas-associated death domain (FADD) expression by quantitative RT-PCR, ... Cited by 5 - Related articles - BL Direct - All 3 versions
- ►yale.edu [PDF] JA Hebda, AD Miranker - Annual Review of Biophysics, 2009 - Annual Reviews The dynamics, energies, and structures governing protein folding are critical to
biological function. Amyloidoses are a class of disease defined, in part, by the
misfolding and aggregation of functional protein precursors into fibrillar ... Cited by 1 - Related articles - All 4 versions
JA Emamaullee, S Merani, C Toso, T Kin, F Al … - Endocrinology, 2009 - Endocrine Soc Although insulin independence is maintained in most islet recipients at 1 yr
after transplant, extended follow-up has revealed that many patients will
eventually require insulin therapy. Previous studies have shown that islet ... Cited by 1 - Related articles - All 3 versions
