ED Abel, SE Litwin, G Sweeney - Physiological Reviews, 2008 - Am Physiological Soc The dramatic increase in the prevalence of obesity and its strong association with cardiovascular
disease have resulted in unprecedented interest in understanding the effects of obesity on the
cardiovascular system. A consistent, but puzzling clinical observation is that obesity ... Cited by 25 - Related articles - BL Direct - All 3 versions
- ►physiology.org MS Bray, CA Shaw, MWS Moore, RAP … - American Journal of …, 2008 - Am Physiological Soc Virtually every mammalian cell, including cardiomyocytes, possesses an intrinsic circadian
clock. The role of this transcriptionally based molecular mechanism in cardiovascular biology
is poorly understood. We hypothesized that the circadian clock within the cardiomyocyte ... Cited by 17 - Related articles - BL Direct - All 7 versions
H Bugger - Clinical Science, 2008 - clinsci.org The metabolic syndrome represents a cluster of abnormalities, including obesity, insulin
resistance, dyslipidaemia and Type 2 diabetes, that increases the risk of developing cardiovascular
diseases, such as coronary artery disease and heart failure. The heart failure risk is ... Cited by 13 - Related articles - Cached - BL Direct - All 7 versions
- ►physiology.org JJ Lehman, S Boudina, NH Banke, N … - American Journal of …, 2008 - Am Physiological Soc High-capacity mitochondrial ATP production is essential for normal function of the adult
heart, and evidence is emerging that mitochondrial derangements occur in common myocardial
diseases. Previous overexpression studies have shown that the inducible transcriptional ... Cited by 9 - Related articles - All 5 versions
H Bugger, S Boudina, XX Hu, J Tuinei, VG Zaha, HA … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Resting cardiac function was normal in Akita mice, and myocardial insulin sensitivity
was preserved. Although Akita hearts oxidized more fatty acids, myocardial O 2 consumption
was not increased, and cardiac efficiency was not reduced. ADP-stimulated mitochondrial ... Cited by 9 - Related articles - All 4 versions
- ►endojournals.org J Kim, AR Wende, S Sena, HA Theobald, J Soto, … - Molecular …, 2008 - Endocrine Soc The receptors for IGF-I (IGF-IR) and insulin (IR) have been implicated in physiological cardiac
growth, but it is unknown whether IGF-IR or IR signaling are critically required. We generated
mice with cardiomyocyte-specific knockout of IGF-IR (CIGF1RKO) and compared them ... Cited by 7 - Related articles - All 5 versions
JA Herlein, BD Fink, Y O'Malley, WI Sivitz - Endocrinology, 2009 - Endocrine Soc Mitochondrial reactive oxygen species have been implicated in both diabetic complications and
the progression of the underlying diabetic state. However, it is not clear whether mitochondria
of diabetic origin are intrinsically altered to generate excess reactive oxygen species ... Cited by 5 - Related articles - All 3 versions
R Harmancey, CR Wilson, H Taegtmeyer - Hypertension, 2008 - Am Heart Assoc Obesity appears to be a major cause of hypertension and associated cardiovascular
pathophysiology, including cardiac dysfunction. However, obesity may lead to abnormal cardiac
function through mechanisms that are independent of, or that act in concert with, ... Cited by 6 - Related articles - All 5 versions
- ►endojournals.org I Tabbi-Anneni, J Buchanan, RC Cooksey, ED Abel - Endocrinology, 2008 - Endocrine Soc The goal of this study was to determine whether inhibiting the renin-angiotensin system would
restore insulin signaling and normalize substrate use in hearts from obese ob/ob mice. Mice
were treated for 4 wk with Captopril (4 mg/kg·d). Circulating levels of free fatty acids, ... Cited by 6 - Related articles - All 4 versions
