D Eizirik, F Moore, D Flamez, F Ortis - Biochemical Society Transactions, 2008 - biochemsoctrans.org Accumulating evidence indicates that β-cells die by apoptosis in T1DM (Type 1
diabetes mellitus). Apoptosis is an active gene-directed process, and recent
observations suggest that β-cell apoptosis depends on the parallel and/or ... Cited by 9 - Related articles - Cached - BL Direct - All 6 versions
E Lien, D Zipris - Current Molecular Medicine, 2009 - ingentaconnect.com 1 Department of Medicine, University of Massachusetts Medical School, Worcester,
MA 01655, USA 2 Department of Pediatrics, Barbara Davis Center for Childhood
Diabetes, University of Colorado, Aurora, CO 80045, USA Abstract: Toll-like ... Cited by 5 - Related articles - All 2 versions
D Zipris - Current Opinion in Endocrinology, Diabetes and …, 2008 - journals.lww.com Purpose of review: Over the last 2 decades, studies addressing mechanisms of
type 1 diabetes have focused primarily on the role of T lymphocytes in disease
mechanisms. Recent investigations, however, suggest that the innate immune ... Cited by 4 - Related articles - All 3 versions
HE Thomas, MD McKenzie, E Angstetra, PD … - Apoptosis - Springer Abstract Apoptosis of beta cells is a feature of both type 1 and type 2 diabetes
as well as loss of islets after trans- plantation. In type 1 diabetes, beta
cells are destroyed by immunological mechanisms. In type 2 diabetes ... Cited by 1 - Related articles - All 2 versions
E Angstetra, KL Graham, S Emmett, NL Dudek … - Immunology and Cell Biology, 2008 - nature.com CD4 + T cells can actively kill -cells in type I diabetes as well as help CD8 +
T cells become cytolytic. Cytokines have the potential to kill -cells, or
upregulate Fas on -cells, and increase their susceptibility to FasL. We ... Related articles - All 2 versions
J Mysliwska, K Zorena, M Mysliwiec, E … - Pediatric Research, 2009 - journals.lww.com Department of Immunology [JM, KZ, EM], Medical University of Gdansk, De˛binki,
80-210 Gdansk, Poland; Academic Clinic of Paediatrics, Haematology, Oncology and
Endocrinology [MM, AB] and Academic Clinic of Ophthalmology [KR], Medical ... Related articles - All 5 versions
TR Wolter, R Wong, SA Sarkar, D Zipris - Clinical Immunology, 2009 - Elsevier We have recently demonstrated that upregulation of the innate immune system
plays a key role in KRV-induced autoimmune diabetes in the BBDR rat, but the
nature of this proinflammatory reaction has not yet been addressed. Using a ... Related articles - All 2 versions