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Scholar Results 1 - 10 of about 43 citing Chang: Association study of the genetic polymorphisms of the transcription factor 7-like.... (0.14 sec) 

Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, …

- nih.gov
MCY Ng, KS Park, B Oh, CHT Tam, YM Cho, … - Diabetes, 2008 - Am Diabetes Assoc
RESULTS— We confirmed the associations of TCF7L2, SLC30A8, HHEX, CDKAL1,
CDKN2A/CDKN2B, IGF2BP2, and FTO with risk for type 2 diabetes, with odds ratios
ranging from 1.13 to 1.35 (1.3 × 10 −12 < P unadjusted < 0.016). In ...
Cited by 51 - Related articles - All 4 versions

Variants in the fat mass–and obesity-associated (FTO) gene are not associated with …

- pubget.com [PDF] 
H Li, Y Wu, RJF Loos, FB Hu, Y Liu, J Wang, Z … - Diabetes, 2008 - Am Diabetes Assoc
RESULTS— The minor allele frequencies of rs8050136, rs9939609, and rs9930506
in our population (0.12, 0.12, and 0.20, respectively) were substantially lower
than those observed for populations of European descent (eg, for CEU ...
Cited by 48 - Related articles - BL Direct - All 5 versions

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: …


JC Florez - Diabetologia, 2008 - Springer
Abstract Although type 2 diabetes has been traditionally understood as a
metabolic disorder initiated by insulin resistance, it has recently become
apparent that an impairment in insulin secretion contributes to its mani- ...
Cited by 31 - Related articles - BL Direct - All 3 versions

Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 …


K Miyake, Y Horikawa, K Hara, K Yasuda, H … - Journal of Human Genetics, 2008 - Springer
Abstract Transcription factor 7-like 2 (TCF7L2) has been shown to be associated
with type 2 diabetes mellitus in multiple ethnic groups. Regarding the Asian
population, Horikoshi et al. (Diabetologia 50:747–751, 2007) and Hayashi ...
Cited by 21 - Related articles - BL Direct - All 3 versions

TCF7L2 genetic defect and type 2 diabetes


S Cauchi, P Froguel - Current Diabetes Reports, 2008 - Springer
After two decades of limited success, the genetic architecture of type 2
diabetes (T2D) is finally being revealed. Within only 2 years, an avalanche of
studies identified several genes expressed in pancreatic ß cells and ...
Cited by 13 - Related articles - BL Direct - All 2 versions

Diabetes in Asia: epidemiology, risk factors, and pathophysiology


JCN Chan, V Malik, W Jia, T Kadowaki, CS … - Jama, 2009 - Am Med Assoc
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Cited by 12 - Related articles - All 4 versions

The WNT signalling pathway and diabetes mellitus


T Jin - Diabetologia, 2008 - Springer
Abstract The WNT signalling pathway is involved in many physiological and
pathophysiological activities. WNT ligands bind to Frizzled receptors and
co-receptors (LDL receptor-related protein 5/6), triggering a cascade of ...
Cited by 12 - Related articles - All 3 versions

Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes …

- phbjmu.edu.cn [PDF] 
Q Ren, XY Han, F Wang, XY Zhang, LC Han, … - Diabetologia, 2008 - Springer
Abstract Aims/hypothesis Recently, variants in the transcription factor 7-like 2
(TCF7L2) gene have been found to be consistently associated with type 2 diabetes
in different populations. In this study, we hypothesized that TCF7L2 also ...
Cited by 11 - Related articles - BL Direct - All 5 versions

Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers …


H Saadi, N Nagelkerke, SG Carruthers, S … - Diabetes Research and Clinical Practice, 2008 - Elsevier
We genotyped the two TCF7L2 single nucleotide polymorphisms (SNPs) rs12255372
and rs7903146 in 368 adult subjects. Homeostatic model assessment (HOMA) was
used to assess beta cell function (HOMA2-%B) and insulin resistance ...
Cited by 6 - Related articles - All 14 versions

Minireview: The Wnt Signaling Pathway Effector TCF7L2 and Type 2 Diabetes Mellitus

- endojournals.org
T Jin, L Liu - Molecular Endocrinology, 2008 - Endocrine Soc
Since the relationship between TCF7L2 (also known as TCF-4) polymorphisms and
type 2 diabetes mellitus was identified in 2006, extensive genome-wide
association examinations in different ethnic groups have further confirmed ...
Cited by 6 - Related articles - All 4 versions


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