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Scholar Results 1 - 5 of 5 citing Wideman: A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted α-Cells.... (0.07 sec) 

The role of incretins in glucose homeostasis and diabetes treatment

- nih.gov
W Kim, JM Egan - Pharmacological reviews, 2008 - ASPET
Cited by 12 - Related articles - All 5 versions

Mechanisms underlying proglucagon gene expression

- endocrinology-journals.org
T Jin - Journal of Endocrinology, 2008 - Soc Endocrinology
The proglucagon gene (gcg) encodes a number of peptide hormones that are of cell-type specifically
expressed in the pancreatic islets, the distal ileum and the large intestine, as well as certain brain
neuronal cells. These hormones are important in controlling blood glucose homeostasis, ...
Cited by 3 - Related articles - All 8 versions

Transplantation of PC1/3-Expressing α-cells Improves Glucose Handling and Cold …


RD Wideman, SL Gray, SD Covey, GC Webb, TJ Kieffer - 2008 - nature.com
Type 2 diabetes (T2D) is characterized by elevated blood glucose levels owing to insufficient
secretion and/or activity of the glucose-lowering hormone insulin. Glucagon-like peptide-1
(GLP-1) has received much attention as a new treatment for diabetes because of its ...
Cited by 1 - Related articles - All 4 versions

Mining incretin hormone pathways for novel therapies


RD Wideman, TJ Kieffer - Trends in Endocrinology & Metabolism, 2009 - Elsevier
The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like
peptide-1 (GLP-1), are produced predominantly by enteroendocrine cells and have multiple
blood glucose-lowering effects. Recent years have seen a surge of interest in ...
Related articles - All 3 versions

Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2

- nih.gov
LS Katz, Y Gosmain, E Marthinet, J … - Molecular and Cellular …, 2009 - Am Soc Microbiol
Pax6 is important in the development of the pancreas and was previously shown to regulate
pancreatic endocrine differentiation, as well as the insulin, glucagon, and somatostatin
genes. Prohormone convertase 2 (PC2) is the main processing enzyme in pancreatic ...
Related articles - All 4 versions


 


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