WP Cawthorn, JK Sethi - FEBS letters, 2008 - Elsevier Dyslipidemia and insulin resistance are commonly associated with catabolic or lipodystrophic
conditions (such as cancer and sepsis) and with pathological states of nutritional overload (such
as obesity-related type 2 diabetes). Two common features of these metabolic disorders ... Cited by 40 - Related articles - All 12 versions
S Schenk, M Saberi, JM Olefsky - The Journal of Clinical …, 2008 - pubmedcentral.nih.gov Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of
a number of diseases, including type 2 diabetes. In this review, we discuss potential mechanisms
by which brief nutrient excess and obesity lead to insulin resistance and propose that ... Cited by 47 - Related articles - All 12 versions
- ►endojournals.org N Rasouli, PA Kern - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Context: Adipose tissue is increasingly recognized as an active endocrine organ with many secretory
products and part of the innate immune system. With obesity, macrophages infiltrate adipose
tissue, and numerous adipocytokines are released by both macrophages and adipocytes. ... Cited by 40 - Related articles - All 3 versions
LK Heilbronn, LV Campbell - Current Pharmaceutical Design, 2008 - ingentaconnect.com Abstract: Obesity was first described as a low-grade inflammatory condition more than a decade
ago. However, it is only relatively re- cently that obese individuals have been described with
increased macrophage infiltration of adipose tissue, as well as an increase in the number ... Cited by 36 - Related articles - BL Direct - All 2 versions
SA Shore - The Journal of Allergy and Clinical Immunology, 2008 - Elsevier Epidemiologic data indicate that obesity increases the prevalence and incidence of asthma and
reduces asthma control. Obese mice exhibit innate airway hyperresponsiveness and augmented
responses to certain asthma triggers, further supporting a relationship between obesity ... Cited by 35 - Related articles - All 40 versions
- ►jlr.org I Murano, G Barbatelli, V Parisani, C Latini, G … - The Journal of Lipid …, 2008 - ASBMB Accumulation of visceral fat is a key phenomenon in the onset of obesity-associated metabolic
disorders. Macrophage infiltration induces chronic mild inflammation widely considered as a
causative factor for insulin resistance and eventually diabetes. We previously showed that ... Cited by 21 - Related articles - All 5 versions
- ►ahajournals.org CM Apovian, S Bigornia, M Mott, MR Meyers, … - … , and vascular biology, 2008 - Am Heart Assoc Methods and Results— We collected subcutaneous abdominal fat in 77 obese subjects (BMI
30 kg/m 2 ) and quantified adipose macrophage population using targeted
immunohistochemistry. Brachial artery vasodilator function was examined using high- ... Cited by 19 - Related articles - All 8 versions
- ►nih.gov D Patsouris, PP Li, D Thapar, J Chapman, JM Olefsky, … - Cell metabolism, 2008 - Elsevier Obese adipose tissue is characterized by infiltration of macrophages. We and others recently
showed that a specific subset of macrophages is recruited to obese adipose and muscle
tissue. This subset expresses CD11c and produces high levels of proinflammatory ... Cited by 17 - Related articles - All 7 versions
CN Lumeng, JB DelProposto, DJ Westcott, AR Saltiel - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Resident ATMs in lean mice express the M2a marker macrophage galactose
N-acetyl-galactosamine specific lectin 1 (MGL1) and localize to interstitial spaces between adipocytes
independent of CCR2 and CCL2. With diet-induced obesity, MGL1 + ATMs remain in ... Cited by 16 - Related articles - All 3 versions
- ►physiology.org C Pang, Z Gao, J Yin, J Zhang, W Jia, … - American Journal of …, 2008 - Am Physiological Soc The biological role of macrophage infiltration into adipose tissue in obesity remains to be fully
understood. We hypothesize that macrophages may act to stimulate angiogenesis in the adipose
tissue. This possibility was examined by determining macrophage expression of ... Cited by 14 - Related articles - All 4 versions
