K Aston-Mourney, J Proietto, G Morahan, S … - Diabetologia, 2008 - Springer Abstract In many countries, first- or second-line pharma- cological treatment of patients with type
2 diabetes consists of sulfonylureas (such as glibenclamide [known as glyburide in the USA
and Canada]), which stimulate the beta cell to secrete insulin. However, emerging ... Cited by 12 - Related articles - BL Direct - All 3 versions
C Xiao, A Giacca, GF Lewis - Diabetologia, 2008 - Springer Page 1. ARTICLE Oral taurine but not N-acetylcysteine ameliorates NEFA-induced
impairment in insulin sensitivity and beta cell function in obese and overweight,
non-diabetic men C. Xiao & A. Giacca & GF Lewis Received ... Cited by 8 - Related articles - BL Direct - All 2 versions
V Poitout, J Amyot, M Semache, B Zarrouki, D … - BBA-Molecular and Cell …, 2009 - Elsevier The concept of glucolipotoxicity refers to the combined, deleterious effects of elevated
glucose, and fatty acid levels on pancreatic beta-cell function and survival. Significant progress
has been made in recent years towards a better understanding of the cellular and ... Cited by 9 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org E Diakogiannaki, HJ Welters, NG Morgan - Journal of Endocrinology, 2008 - Soc Endocrinology Exposure of pancreatic β-cells to long-chain fatty acids leads to the activation of some components
of the endoplasmic reticulum (ER) stress pathway and this mechanism may underlie the ability
of certain fatty acids to promote β-cell death. We have studied ER stress in BRIN-BD11 β- ... Cited by 7 - Related articles - BL Direct - All 4 versions
E Diakogiannaki, N Morgan - Biochemical Society Transactions, 2008 - biochemsoctrans.org Recent evidence indicates that treatment of pancreatic β-cells with long chain fatty acids can
lead to the development of an ER (endoplasmic reticulum) stress response. This is manifest as
the activation of some components of the PERK [RNA-dependent protein kinase-like ER ... Cited by 7 - Related articles - Cached - All 3 versions
SE Choi, YJ Lee, HJ Jang, KW Lee, YS Kim, HS … - Archives of biochemistry …, 2008 - Elsevier Free fatty acids (FFAs) are believed to be a stimulus to elicit beta cell dysfunction. The present
study was undertaken to determine whether endoplasmic reticulum (ER) stress was involved
in palmitate-induced inhibition of glucose-stimulated insulin secretion (GSIS) and whether ... Cited by 5 - Related articles - All 4 versions
SE Choi, SM Lee, YJ Lee, LJ Li, SJ Lee, JH Lee, Y Kim, … - Endocrinology, 2009 - Endocrine Soc Autophagy, a vacuolar degradative pathway, constitutes a stress adaptation that avoids cell death
or elicits the alternative cell-death pathway. This study was undertaken to determine whether
autophagy is activated in palmitate (PA)-treated β-cells and, if activated, what the role of ... Cited by 5 - Related articles - All 3 versions
K Cusi - Springer The epidemic of type 2 diabetes (T2DM) is a public health problem that threatens to spiral out
of control in the twenty-first century. Early intervention can greatly mitigate the serious socioeconomic
impact of the disease, driven largely by disabling microvascular complications and ... Cited by 2 - Related articles - All 2 versions
EM Carneiro, MQ Latorraca, E Araujo, M Beltrá, MJ … - The Journal of Nutritional …, 2009 - Elsevier Taurine is a conditionally essential amino acid for human that is involved in the control of glucose
homeostasis; however, the mechanisms by which the amino acid affects blood glucose levels
are unknown. Using an animal model, we have studied these mechanisms. Mice were ... Cited by 1 - Related articles - All 5 versions
- ►endocrinology-journals.org G Bikopoulos, A da Silva Pimenta, SC Lee, … - Journal of …, 2008 - Soc Endocrinology The aim of this study was to assess the effects of chronic free fatty acid (FFA) exposure on gene
expression and the functional state of human pancreatic islets. Chronic exposure of islets to oleate
(OA) resulted in a significant reduction in glucose-stimulated insulin secretion (GSIS) ... Related articles - BL Direct - All 6 versions
