- ►rupress.org MMW Chong, JP Rasmussen, AY Rudensky, … - Journal of Experimental Medicine, 2008 - jem.rupress.org MicroRNAs (miRNAs) are implicated in the differentiation and function of many
cell types. We provide genetic and in vivo evidence that the two RNaseIII
enzymes, Drosha and Dicer, do indeed function in the same pathway. These ... Cited by 18 - Related articles - All 6 versions
- ►uky.edu [PDF] X Tang, G Tang, S Özcan - BBA-Gene Regulatory Mechanisms, 2008 - Elsevier Diabetes is one of the most common chronic diseases in the world. Multiple and
complex factors including various genetic and physiological changes can lead to
type 1 and type 2 diabetes. However, the major mechanisms underlying the ... Cited by 14 - Related articles - All 4 versions
P Lovis, S Gattesco, R Regazzi - Biological Chemistry, 2008 - reference-global.com Fine-tuning of insulin secretion from pancreatic b-cells participates in blood
glucose homeostasis. Defects in this process can lead to chronic hyperglycemia
and dia- betes mellitus. Several proteins controlling insulin exo- cytosis ... Cited by 13 - Related articles - BL Direct - All 3 versions
- ►endojournals.org AK Nagaraja, C Andreu-Vieyra, HL Franco, L … - Molecular Endocrinology, 2008 - Endocrine Soc Dicer is an evolutionarily conserved ribonuclease III that is necessary for
microRNA (miRNA) processing and the synthesis of small interfering RNAs from
long double-stranded RNA. Although it has been shown that Dicer plays ... Cited by 12 - Related articles - All 5 versions
- ►diabetesresearch.org [PDF] V Bravo-Egana, S Rosero, RD Molano, A … - Biochemical and Biophysical Research …, 2008 - Elsevier MicroRNAs (miRNAs) are non-coding gene products that regulate gene expression
through specific binding to target mRNAs. Cell-specific patterns of miRNAs are
associated with the acquisition and maintenance of a given phenotype, such ... Cited by 11 - Related articles - All 4 versions
- ►pnas.org MN Poy, J Hausser, M Trajkovski, M Braun, S … - Proceedings of the National Academy of Sciences, 2009 - National Acad Sciences Altered growth and development of the endocrine pancreas is a frequent cause of
the hyperglycemia associated with diabetes. Here we show that microRNA-375
(miR-375), which is highly expressed in pancreatic islets, is required for ... Cited by 9 - Related articles - All 12 versions
- ►cshlp.org JG Reid, AK Nagaraja, FC Lynn, RB Drabek, … - Genome research, 2008 - genome.cshlp.org Massively parallel sequencing of millions of <30-nt RNAs expressed in mouse
ovary, embryonic pancreas (E14.5), and insulin-secreting beta-cells (βTC-3)
reveals that ∼50% of the mature miRNAs representing mostly the mmu-let-7 ... Cited by 7 - Related articles - All 11 versions
E Hennessy, L O'Driscoll - Expert Reviews in Molecular Medicine, 2008 - Cambridge Univ Press Small RNAs are a family of regulatory noncoding RNAs up to 40 nucleotides in
length that can induce gene silencing through specific base- pairing with target
mRNA molecules. Apart from their major function of gene regulation (Ref. ... Cited by 7 - Related articles - All 3 versions
- ►cshlp.org X Tang, L Muniappan, G Tang, S Özcan - Rna, 2009 - rnajournal.cshlp.org MicroRNAs (miRNAs) are small noncoding ribonucleotides that bind mRNAs and
function mainly as translational repressors in mammals. MicroRNAs have been
implicated to play a role in many diseases, including diabetes. Several ... Cited by 8 - Related articles - All 4 versions
NJ Hand, ZR Master, J Le Lay, JR Friedman - Hepatology, 2009 - interscience.wiley.com MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene
expression through partial or complete complementarity with target messenger
RNAs. The function of miRNAs in normal liver physiology is largely unknown. ... Cited by 5 - Related articles - All 2 versions
