K Reue, DN Brindley - The Journal of Lipid Research, 2008 - ASBMB Phosphatidate phosphatase-1 (PAP1) enzymes have a key role in glycerolipid synthesis through
the conversion of phosphatidate to diacylglycerol, the immediate precursor of triacylglycerol,
phosphatidylcholine, and phosphatidylethanolamine. PAP1 activity in mammals is ... Cited by 10 - Related articles - All 7 versions
K Reue, JR Dwyer - The Journal of Lipid Research, 2009 - ASBMB The lipin protein family consists of three members, lipin-1, lipin-2, and lipin-3. The founding member
of the family, lipin-1, was identified via positional cloning as the mutated gene product in the
fatty liver dystrophy (fld) mouse (1). The name of the mutation refers to the occurrence of ... Cited by 3 - Related articles - All 5 versions
H Joost - Obesity Facts, 2008 - content.karger.com Type 2 diabetes mellitus is a complex, polygenic disease with a heterogeneous
pathophysiology, mainly characterised by obesity-associated insulin resistance and a progressive
failure of pancreatic -cells. Predominant risk factors for its development are abdominal ... Cited by 2 - Related articles - All 3 versions
K Takeuchi, K Reue - American Journal of Physiology- …, 2009 - Am Physiological Soc Triacylglycerol (TAG) synthesis and storage in tissues such as adipose tissue and liver have
important roles in metabolic homeostasis. The molecular identification of genes encoding enzymes
that catalyze steps in TAG biosynthesis from glycerol 3-phosphate has revealed an ... Cited by 2 - Related articles - All 4 versions
K Reue, J Donkor - Diabetes, 2007 - Am Diabetes Assoc Type 2 diabetes was once referred to as a “geneticist's nightmare” (1) due to difficulties stemming
from the nature of the disease and the strategies available for genetic analysis. Two key genetic
approaches previously utilized—linkage analysis and candidate gene association ... Cited by 2 - Related articles - BL Direct - All 3 versions
X He, X Xu, B Liu - Molecular Biology Reports, 2009 - Springer Abstract The products of mammalian LPIN2 and LPIN3 are phosphatidate phosphatase type
1 enzymes, which play an important role in the de novo biosynthesis of triacylglycerol, phosphatidylcholine
and phosphatidyleth- anolamine. In this study, we obtained a 2,985-bp cDNA sequence ... Cited by 1 - Related articles - All 2 versions
MAS Dehwah, Z Shuang, WZ Hua, W Min, QY … - Journal of Applied …, 2009 - scialert.net J. Applied Sci, 9 (19); 3407-3423, 2009 2007). Family, history of T2DM has a significant, independent
and graded association with the prevalence of T2DM. In twins studies, very high concordance
(55 to 100%) for T2DM has been reported among monozygotic (MZ) twins (Newman et ... Related articles - All 6 versions
MC Gropler, TE Harris, AM Hall, NE Wolins, RW … - Journal of Biological …, 2009 - ASBMB Lipin 1 is a bifunctional intracellular protein that regulates fatty acid metabolism in the nucleus
via interactions with DNA-bound transcription factors and at the endoplasmic reticulum as a phosphatidic
acid phosphohydrolase enzyme (PAP-1) to catalyze the penultimate step in triglyceride ... Related articles - All 4 versions
K Reue, J Donkor - DIABETES, 2007 - Am Diabetes Assoc T ype 2 diabetes was once referred to as a “genet- icist's nightmare” (1) due to difficulties stemming
from the nature of the disease and the strategies available for genetic analysis. Two key genetic
approaches previously utilized—linkage analysis and can- didate gene association ... Related articles