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Scholar Results 1 - 10 of about 33 citing Florez: A 100K Genome-Wide Association Scan for Diabetes and Related Traits in the Framingham.... (0.08 sec) 

Meta-analysis of genome-wide association data and large-scale replication …


E Zeggini, LJ Scott, R Saxena, BF Voight, JL … - Nature …, 2008 - pubmedcentral.nih.gov
Cited by 269 - Related articles - BL Direct - All 7 versions

Identification of novel candidate genes for type 2 diabetes from a genome-wide …

- diabetesjournals.org [PDF] 
E Rampersaud, CM Damcott, M Fu, H Shen, P McArdle, … - Diabetes, 2007 - Am Diabetes Assoc
Evadnie Rampersaud 1 , Coleen M. Damcott 1 , Mao Fu 1 , Haiqing Shen 1 , Patrick McArdle
1 , ... Xiaolian Shi 1 , John Shelton 1 , Jing Yin 1 ,Christy Y. Chang 1 ,Sandra H. Ott 1 , Li Zhang
1 , ... Yiju Zhao 1 , Braxton D. Mitchell 1 , Jeffery O'Connell 1 , and Alan R. Shuldiner 1,2
Cited by 45 - Related articles - BL Direct - All 6 versions

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 …


JC Florez - Diabetologia, 2008 - Springer
Abstract Although type 2 diabetes has been traditionally understood as a metabolic disorder
initiated by insulin resistance, it has recently become apparent that an impairment in insulin secretion
contributes to its mani- festation and may play a prominent role in its early ...
Cited by 31 - Related articles - BL Direct - All 3 versions

Identification of type 2 diabetes genes in Mexican Americans through genome- …


MG Hayes, A Pluzhnikov, K Miyake, Y Sun, MCY Ng, … - Diabetes, 2007 - Am Diabetes Assoc
RESULTS—We observed more significant allelic associations than expected genome wide,
as empirically assessed by permutation (14 below a P of 1 × 10 −4 [8.7 expected]). No significant
differences were observed between the proportion of ancestry estimates in the case and ...
Cited by 34 - Related articles - BL Direct - All 4 versions

A search for variants associated with young-onset type 2 diabetes in American …


RL Hanson, C Bogardus, D Duggan, S Kobes, M … - Diabetes, 2007 - Am Diabetes Assoc
RESEARCH DESIGN AND METHODS— Data come from 300 case subjects with type 2 diabetes
with age of onset <25 years and 334 nondiabetic control subjects aged ≥45 years. To provide
for tests of within-family association, 121 nondiabetic siblings of case subjects were ...
Cited by 30 - Related articles - BL Direct - All 3 versions

Post genome-wide association studies of novel genes associated with type 2 …


S Cauchi, D Meyre, E Durand, C Proença, M Marre, S … - PloS one, 2008 - pubmedcentral.nih.gov
In the same French population analyzed in our previous GWA study (3,295 T2D and 3,595
NGT), strong associations with T2D were found for CDKAL1 (OR rs7756992 =
1.30[1.19–1.42], P = 2.3×10 −9 ), CDKN2A/2B (OR rs10811661 = 0.74[0.66–0.82], P = ...
Cited by 21 - Related articles - All 7 versions

Analysis of novel risk loci for type 2 diabetes in a general French population: the …

- pubget.com [PDF] 
S Cauchi, C Proença, H Choquet, S Gaget, F De … - Journal of Molecular …, 2008 - Springer
Page 1. RAPID COMMUNICATION Analysis of novel risk loci for type 2 diabetes in
a general French population: the DESIR study Stéphane Cauchi & Christine Proença
& Hélène Choquet & Stefan Gaget & Franck De Graeve & ...
Cited by 16 - Related articles - BL Direct - All 3 versions

Type 2 diabetes: new genes, new understanding

- cell.com
I Prokopenko, MI McCarthy, CM Lindgren - Trends in Genetics, 2008 - Elsevier
Over the past two years, there has been a spectacular change in the capacity to identify common
genetic variants that contribute to predisposition to complex multifactorial phenotypes such as
type 2 diabetes (T2D). The principal advance has been the ability to undertake surveys of ...
Cited by 15 - Related articles - All 7 versions

Comprehensive association study of type 2 diabetes and related quantitative traits …

- diabetesjournals.org
KJ Gaulton, CJ Willer, Y Li, LJ Scott, KN Conneely, AU … - Diabetes, 2008 - Am Diabetes Assoc
RESEARCH DESIGN AND METHODS—In a case-control study of 1,161 type 2 diabetic subjects
and 1,174 control Finns who are normal glucose tolerant, we genotyped 3,531 tagSNPs and
annotation-based SNPs and imputed an additional 7,498 SNPs, providing 99.9% ...
Cited by 12 - Related articles - All 6 versions

The genetics of type 2 diabetes: a realistic appraisal in 2008

- geyseco.info [PDF] 
JC Florez - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc
Evidence Synthesis: As many as 17 genetic loci have been convincingly associated with type
2 diabetes; 14 of these were not previously known, and most of them were unsuspected. The
associated polymorphisms are common in populations of European descent but have ...
Cited by 12 - Related articles - All 4 versions


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