- ►nih.gov MCY Ng, KS Park, B Oh, CHT Tam, YM Cho, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— We confirmed the associations of TCF7L2, SLC30A8, HHEX, CDKAL1,
CDKN2A/CDKN2B, IGF2BP2, and FTO with risk for type 2 diabetes, with odds ratios
ranging from 1.13 to 1.35 (1.3 × 10 −12 < P unadjusted < 0.016). In ... Cited by 51 - Related articles - All 4 versions
- ►diabetesjournals.org [PDF] RM Freathy, NJ Timpson, DA Lawlor, A Pouta, … - Diabetes, 2008 - Am Diabetes Assoc Page 1. Common variation in the FTO gene alters diabetes-related metabolic
traits to the extent expected, given its effect on BMI ... Cited by 40 - Related articles - BL Direct - All 3 versions
K Kirchhoff, F Machicao, A Haupt, SA Schäfer, … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Variation within six novel genetic loci has been
reported to confer risk of type 2 diabetes and may be associated with beta cell
dysfunction. We investigated whether these polymorphisms are also ... Cited by 38 - Related articles - BL Direct - All 3 versions
JC Florez - Diabetologia, 2008 - Springer Abstract Although type 2 diabetes has been traditionally understood as a
metabolic disorder initiated by insulin resistance, it has recently become
apparent that an impairment in insulin secretion contributes to its mani- ... Cited by 31 - Related articles - BL Direct - All 3 versions
H Lango, CNA Palmer, AD Morris, E Zeggini, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVES—Genome-wide association studies have dramatically increased the
number of common genetic variants that are robustly associated with type 2
diabetes. A possible clinical use of this information is to identify ... Cited by 28 - Related articles - All 5 versions
- ►nih.gov Y Wu, H Li, RJF Loos, Z Yu, X Ye, L Chen, A … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— We confirmed the associations between type 2 diabetes and variants
near CDKAL1 (odds ratio 1.49 [95% CI 1.27–1.75]; P = 8.91 × 10 −7 ) and
CDKN2A/B (1.31 [1.12–1.54]; P = 1.0 × 10 −3 ). We observed significant ... Cited by 28 - Related articles - All 5 versions
TW Boesgaard, J Žilinskaitė, M Vänttinen, … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis A recent genome-wide association study identified the
SLC30A8 rs13266634 polymorphism encoding an Arg325Trp polymorphism in the zinc
transporter protein member 8 (ZnT-8) to be associated with type 2 diabetes. ... Cited by 20 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org H Staiger, A Stančáková, J Zilinskaite, M … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—SNPs rs1111875 and rs7923837 were not associated with anthropometric
data (age, weight, height, BMI, body fat, and waist and hip circumference).
After adjustment for center, family relationship, sex, age, and BMI, both ... Cited by 17 - Related articles - BL Direct - All 4 versions
JRB Perry, TM Frayling - Current Opinion in Clinical Nutrition & Metabolic Care, 2008 - journals.lww.com Recent findings: Recent genome-wide association studies have provided an
important resource for furthering our understanding of type 2 diabetes disease
mechanisms. Genes previously unsuspected of playing a role in diabetes are ... Cited by 17 - Related articles - All 2 versions
