A Helgadottir, G Thorleifsson, KP Magnusson, S … - 2008 - nature.com Recently, two common sequence variants on 9p21, tagged by rs10757278-G and
rs10811661-T, were reported to be associated with coronary artery disease (CAD) 1, 2, 3, 4 and
type 2 diabetes (T2D) 5, 6, 7 , respectively. We proceeded to further investigate the ... Cited by 93 - Related articles - BL Direct - All 12 versions
MCY Ng, KS Park, B Oh, CHT Tam, YM Cho, HD Shin, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— We confirmed the associations of TCF7L2, SLC30A8, HHEX, CDKAL1,
CDKN2A/CDKN2B, IGF2BP2, and FTO with risk for type 2 diabetes, with odds ratios ranging
from 1.13 to 1.35 (1.3 × 10 −12 < P unadjusted < 0.016). In addition, the A allele of ... Cited by 51 - Related articles - All 4 versions
JC Florez - Diabetologia, 2008 - Springer Abstract Although type 2 diabetes has been traditionally understood as a metabolic disorder
initiated by insulin resistance, it has recently become apparent that an impairment in insulin secretion
contributes to its mani- festation and may play a prominent role in its early ... Cited by 31 - Related articles - BL Direct - All 3 versions
H Lango, CNA Palmer, AD Morris, E Zeggini, AT … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVES—Genome-wide association studies have dramatically increased the number of
common genetic variants that are robustly associated with type 2 diabetes. A possible clinical
use of this information is to identify individuals at high risk of developing the disease, so ... Cited by 28 - Related articles - All 5 versions
Y Wu, H Li, RJF Loos, Z Yu, X Ye, L Chen, A Pan, FB … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— We confirmed the associations between type 2 diabetes and variants near CDKAL1
(odds ratio 1.49 [95% CI 1.27–1.75]; P = 8.91 × 10 −7 ) and CDKN2A/B (1.31 [1.12–1.54]; P =
1.0 × 10 −3 ). We observed significant association of SNPs in IGF2BP2 (1.17 [1.03–1.32]; ... Cited by 28 - Related articles - All 5 versions
S Cauchi, D Meyre, E Durand, C Proença, M Marre, S … - PloS one, 2008 - pubmedcentral.nih.gov In the same French population analyzed in our previous GWA study (3,295 T2D and 3,595
NGT), strong associations with T2D were found for CDKAL1 (OR rs7756992 =
1.30[1.19–1.42], P = 2.3×10 −9 ), CDKN2A/2B (OR rs10811661 = 0.74[0.66–0.82], P = ... Cited by 21 - Related articles - All 7 versions
- ►endojournals.org Y Horikawa, K Miyake, K Yasuda, M Enya, Y … - Journal of Clinical …, 2008 - Endocrine Soc Results: A total of 15 SNPs were genotyped. Eight SNPs in five loci were found to be associated
with type 2 diabetes: rs3802177 [odds ratio (OR) = 1.16 (95% confidence interval (CI)
1.05–1.27); P = 4.5 x 10 –3 ] in SLC30A8; rs1111875 [OR = 1.27 (95% CI 1.14–1.40); P = ... Cited by 20 - Related articles - All 3 versions
- ►diabetesjournals.org H Staiger, A Stančáková, J Zilinskaite, M Vänttinen, T … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—SNPs rs1111875 and rs7923837 were not associated with anthropometric data
(age, weight, height, BMI, body fat, and waist and hip circumference). After adjustment for
center, family relationship, sex, age, and BMI, both SNPs were also not associated with ... Cited by 17 - Related articles - BL Direct - All 4 versions
JRB Perry, TM Frayling - Current Opinion in Clinical Nutrition & …, 2008 - journals.lww.com Recent findings: Recent genome-wide association studies have provided an important resource
for furthering our understanding of type 2 diabetes disease mechanisms. Genes previously unsuspected
of playing a role in diabetes are now implicated in the disease process. These include ... Cited by 17 - Related articles - All 2 versions
