- ►diabetesjournals.org L Marzban, A Tomas, TC Becker, L Rosenberg, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Thioflavine S–positive amyloid deposits were clearly present after
10 days of culture. Transduction with Ad-hProIAPP-siRNA reduced proIAPP
expression by 75% compared with nontransduced islets as assessed by Western ... Cited by 5 - Related articles - All 3 versions
S Zraika, RL Hull, J Udayasankar, K Aston- … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Islet amyloid in type 2 diabetes contrib- utes to loss
of beta cell mass and function. Since islets are susceptible to oxidative
stress-induced toxicity, we sought to determine whether islet amyloid ... Cited by 4 - Related articles - All 2 versions
RL Hull, S Zraika, J Udayasankar, K Aston- … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Supraphysiological levels of the amyloi- dogenic
peptide human islet amyloid polypeptide have been associated with beta cell
endoplasmic reticulum (ER) stress. However, in human type 2 diabetes, ... Cited by 1 - Related articles - All 2 versions
F Despa - Biophysical Chemistry, 2009 - Elsevier Insulin regulates the energy homeostasis of the human body. This is synthesized
in the endoplasmic reticulum (ER) of pancreatic beta cells from proinsulin.
Chronic hyperglycemia increases considerably the proinsulin secretion, ... Cited by 2 - Related articles - All 3 versions
C IONESCU-TÎRGOVIŞTE, C GUJA - paulescu.ro Based on our clinical and epidemiological data, we have sustained for a long
time the unitary character of the various phenotypes of the diabetic syndrome.
In this paper, we add several arguments sustaining that the unitary ... Related articles - View as HTML - All 2 versions
K Boonen, JW Creemers, L Schoofs - BioEssays, 2009 - interscience.wiley.com Bioactive peptides are a group of diverse intercellular signalling molecules.
Almost half a century of research on this topic has resulted in an enormous
amount of data. In this essay, a general perspective to interpret all these ... Related articles - All 4 versions
J Udayasankar, K Kodama, RL Hull, S Zraika, … - Diabetologia, 2009 - Springer Page 1. ARTICLE Amyloid formation results in recurrence of hyperglycaemia following
transplantation of human IAPP transgenic mouse islets ... Related articles - All 2 versions