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Scholar Results 1 - 10 of 11 citing Davidson: Treatment of Streptozotocin-Induced Diabetic Rats With AVE7688, a Vasopeptidase Inhibitor. (0.11 sec) 

[PDF] Natural products to drugs: natural product derived compounds in clinical trials


MS Butler - Natural product reports, 2005 - rsc.org
Natural product and natural product-derived compounds that are being evaluated in clinical trials
or in registration (current 31 December 2004) have been reviewed. Natural product derived drugs
launched in the United States of America, Europe and Japan since 1998 and new natural ...
Cited by 144 - Related articles - BL Direct - All 14 versions

Role of nitrosative stress in early neuropathy and vascular dysfunction in …

- physiology.org
IG Obrosova, VR Drel, CL Oltman, N … - American Journal of …, 2007 - Am Physiological Soc
Evidence for important roles of the highly reactive oxidant peroxynitrite in diabetic complications
is emerging. We evaluated the role of peroxynitrite in early peripheral neuropathy and vascular
dysfunction in STZ-diabetic rats. In the first dose-finding study, control and STZ-diabetic ...
Cited by 17 - Related articles - BL Direct - All 5 versions

Attenuation of vascular/neural dysfunction in Zucker rats treated with enalapril or …


CL Oltman, EP Davidson, LJ Coppey, TL Kleinschmidt, … - Obesity, 2008 - nature.com
Enalapril treatment decreased serum angiotensin-converting enzyme (ACE) activity and both
drugs reduced serum cholesterol levels. In obese Zucker rats at 32 weeks of age superoxide
levels were elevated in the aortas and epineurial arterioles, which were reduced by ...
Cited by 6 - Related articles - All 3 versions

The potential role of angiotensin converting enzyme and vasopeptidase inhibitors …


MA Yorek - Current Drug Targets, 2008 - ingentaconnect.com
Abstract: Diabetic neuropathy is a debilitating disorder that occurs in more than 50 percent of
patients with diabetes. Evidence suggests that there are at least five major pathways involved
in the development of diabetic neuropathy: meta- bolic, vascular, immunologic, ...
Cited by 4 - Related articles - BL Direct - All 3 versions

Treatment of Zucker diabetic fatty rats with AVE7688 improves vascular and neural …


CL Oltman, EP Davidson, LJ Coppey, TL … - Diabetes, obesity & …, 2009 - pubmedcentral.nih.gov
Vasopeptidase inhibitors are drugs that inhibit angiotensin-converting enzyme and neutral endopeptidase
(NEP). The latter is a protease that degrades vasoactive peptides and is increased in
diabetes. We have previously shown that treating streptozotocin-induced diabetic rats, an ...
Cited by 3 - Related articles - All 5 versions

Peripheral neuropathy in mice with neuronal nitric oxide synthase gene deficiency


I VARENIUK, PAL PACHER, IA PAVLOV, … - … journal of molecular …, 2009 - pubmedcentral.nih.gov
Evidence for the important role of the potent oxidant peroxynitrite in peripheral diabetic neuropathy
and neuropathic pain is emerging. This study evaluated the contribution of neuronal nitric oxide
synthase (nNOS) to diabetes-induced nitrosative stress in peripheral nerve and dorsal ...
Cited by 1 - Related articles - All 4 versions

[PDF] Vascular and Neural Dysfunctions in Obese Zucker Rats: Effect of AVE7688


EP Davidson, LJ Coppey, TL Kleinschmidt, CL … - Experimental Diabetes …, 2009 - hindawi.com
Page 1. Hindawi Publishing Corporation Experimental Diabetes Research Volume 2009,
Article ID 912327, 8 pages doi:10.1155/2009/912327 Research Article Vascular and
Neural Dysfunctions in Obese Zucker Rats: Effect of AVE7688 ...
Cited by 1 - Related articles - View as HTML - All 11 versions

Rosuvastatin positively changes nerve electrophysiology in diabetic rats


K Tarhzaoui, P Valensi, G Leger, F Cohen- … - Diabetes Res Clin …, 2008 - interscience.wiley.com
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Cited by 1 - Related articles - All 3 versions

Vascular and Neural Dysfunctions in Obese Zucker Rats: Effect of AVE7688


P Eric… - Experimental Diabetes Research, 2009 - hindawi.com
The purpose of this study was to determine whether AVE7688 a drug that inhibits both angiotensin
converting enzyme and neutral endopeptidase activity protects vascular and nerve functions
in an animal model of metabolic syndrome. Obese Zucker rats at 20 weeks of age were ...
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[CITATION] Last literature review version 17.1: Thu Jan 01 00: 00: 00 GMT 2009| This topic last …


… , C INHIBITORS, IOFMTOF RAPAMYCIN, IOF PURINE, …
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