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Scholar Results 1 - 10 of about 43 citing Thong: The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activate.... (0.12 sec) 

Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in …


EB Taylor, D An, HF Kramer, H Yu, NL Fujii, … - Journal of Biological Chemistry, 2008 - ASBMB
The Akt substrate of 160 kDa (AS160) is phosphorylated on Akt substrate (PAS)
motifs in response to insulin and contraction in skeletal muscle, regulating
glucose uptake. Here we discovered a dissociation between AS160 protein ...
Cited by 34 - Related articles - All 6 versions

GLUT4 translocation: the last 200 nanometers


RT Watson, JE Pessin - Cellular Signalling, 2007 - Elsevier
Insulin regulates circulating glucose levels by suppressing hepatic glucose
production and increasing glucose transport into muscle and adipose tissues.
Defects in these processes are associated with elevated vascular glucose ...
Cited by 29 - Related articles - All 4 versions

Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1 …


KM Geraghty, S Chen, JE Harthill, AF … - The Biochemical Journal, 2007 - pubmedcentral.nih.gov
AS160 (Akt substrate of 160 kDa) mediates insulin-stimulated GLUT4 (glucose
transporter 4) translocation, but is widely expressed in insulin-insensitive
tissues lacking GLUT4. Having isolated AS160 by 14-3-3-affinity ...
Cited by 28 - Related articles - BL Direct - All 6 versions

Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

- physiology.org
K Sakamoto, GD Holman - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc
Vesicular traffic of the glucose transporter GLUT4 occurs in response to
insulin, muscle contraction, and metabolic stimuli that lead to changes in the
energy status of the cell. These stimuli are associated with linked kinase ...
Cited by 22 - Related articles - All 6 versions

Calmodulin-binding domain of AS160 regulates contraction-but not insulin-stimulated …

- uoguelph.ca [PDF] 
HF Kramer, EB Taylor, CA Witczak, N Fujii, … - Diabetes, 2007 - Am Diabetes Assoc
RESULTS—Immunoprecipitates of wild-type and CBD-mutant AS160 were incubated
with biotinylated calmodulin in the presence of Ca 2+ . Wild-type AS160, but not
the CBD-mutant AS160, associated with calmodulin. Next, we measured ...
Cited by 16 - Related articles - BL Direct - All 4 versions

Skeletal muscle insulin resistance: roles of fatty acid metabolism and exercise

- physicaltherapyjournal.com
LP Turcotte, JS Fisher - Physical Therapy, 2008 - physicaltherapyjournal.com
The purpose of this review is to provide information about the role of exercise
in the prevention of skeletal muscle insulin resistance, that is, the inability
of insulin to properly cause glucose uptake into skeletal muscle. Insulin ...
Cited by 11 - Related articles - All 31 versions

Identification of omentin mRNA in human epicardial adipose tissue: comparison to omentin …


JN Fain, HS Sacks, B Buehrer, SW Bahouth, E … - International Journal of Obesity, 2008 - nature.com
The purpose of this study was to determine the relative distribution of omentin
and visfatin mRNA in human epicardial, peri-internal mammary, upper thoracic,
upper abdominal and leg vein subcutaneous adipose tissue as well as the ...
Cited by 11 - Related articles - BL Direct - All 3 versions

GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A …


VK Randhawa, S Ishikura, I Talior-Volodarsky … - Journal of Biological Chemistry, 2008 - ASBMB
Insulin increases glucose uptake into muscle by enhancing the surface recycling
of GLUT4 transporters. In myoblasts, insulin signals bifurcate downstream of
phosphatidylinositol 3-kinase into separate Akt and Rac/actin arms. ...
Cited by 9 - Related articles - All 4 versions

Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in …


CN Antonescu, M DĂ­az, G Femia, JV Planas, A … - Traffic, 2008 - interscience.wiley.com
In myocytes and adipocytes, insulin increases glucose transporter 4 (GLUT4)
exocytosis by promoting GLUT4 vesicle docking/fusion with the membrane. Less is
known about the mechanism and regulation of GLUT4 endocytosis, particularly ...
Cited by 9 - Related articles - All 3 versions

The effect of exercise and insulin on AS160 phosphorylation and 14-3-3 binding capacity in …

- physiology.org
KF Howlett, A Mathews, A Garnham, K … - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc
AS160 is an Akt substrate of 160 kDa implicated in the regulation of both
insulin- and contraction-mediated GLUT4 translocation and glucose uptake. The
effects of aerobic exercise and subsequent insulin stimulation on AS160 ...
Cited by 10 - Related articles - BL Direct - All 3 versions


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