J Chen, G Saxena, IN Mungrue, AJ Lusis, A Shalev - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Incubation of INS-1 cells at 25 mmol/l glucose for 24 h led to an 18-fold increase
in TXNIP protein, as assessed by immunoblotting. This was accompanied by increased
apoptosis, as demonstrated by a 12-fold induction of cleaved caspase-3. Overexpression ... Cited by 27 - Related articles - BL Direct - All 3 versions
- ►endojournals.org HY Seo, YD Kim, KM Lee, AK Min, MK Kim, HS Kim, KC … - Endocrinology, 2008 - Endocrine Soc The highly developed endoplasmic reticulum (ER) structure of pancreatic β-cells is a key factor
in β-cell function. Here we examined whether ER stress-induced activation of activating transcription
factor (ATF)-6 impairs insulin gene expression via up-regulation of the orphan nuclear ... Cited by 10 - Related articles - All 4 versions
- ►endojournals.org [PDF] HY Seo, YD Kim, KM Lee, AK Min, MK Kim, HS Kim, KC … - Endocrinology, 2008 - Endocrine Soc Kim, 2 Hye-Soon Kim, 2 Kyu-Chang Won, 3 Joong-Yeol Park, 4 Ki-Up Lee, 4 Hueng-Sik ...
Choi, 5 Keun-Gyu Park, 2* and In-Kyu Lee 1* ... Institutions: 1 Department of Internal Medicine
and Biochemistry and Cell Biology, Kyungpook National University School of Medicine, ... Cited by 1 - Related articles
MK Kim, HS Jung, CS Yoon, MJ Kwon, KS Koh, BD … - synapse.koreamed.org Oxidative stress is important in both diabetic complications and the development and the progression
of type 2 diabetes via the effects on the pancreatic β-cells. EGCG (epigallocatechin
galleate), a major constituent of green tea, has been known to have beneficial effects on ... Related articles - Cached - All 2 versions
TH Kim, H Kim, JM Park, SS Im, JS Bae, MY Kim, … - Journal of Biological …, 2009 - ASBMB 1 , Brain Korea 21 Project for Medical Sciences 2 , ... Yonsei University College of Medicine,
134 Shinchon-dong, Seodaemoon-gu, ... Lee Gil Ya Cancer and Diabetes Institute, Gachon
University of Medicine and Science ... # These authors contributed equally to this work. Related articles - All 2 versions
J Chen, G Saxena, IN Mungrue, AJ Lusis, A Shalev - DIABETES, 2008 - Am Diabetes Assoc Type 2 diabetes is a growing public health issue characterized by peripheral insulin resistance
and decompensation of the pancreatic -cells that can no longer keep up with the increased insulin
requirements, resulting in hyperglycemia. These elevated glucose levels have ...
TH Kim, H Kim, JM Park, SS Im, JS Bae, MY Kim, … - Journal of Biological …, 2009 - ASBMB Liver glucokinase (LGK) plays an essential role in controlling blood glucose levels and maintaining
cellular metabolic functions. Expression of LGK is induced mainly regulated by insulin through
sterol regulatory element-binding protein-1c (SREBP-1c) as a mediator. Since LGK ... Cited by 1 - Related articles - All 2 versions
P Gao, Y Jiao, Q Xiong, CY Wang, I Gerling, … - Current …, 2008 - pubmedcentral.nih.gov A systematic study has been conducted of all available reports in PubMed and OMIM (Online
Mendelian Inheritance in Man) to examine the genetic and molecular basis of quantitative genetic
loci (QTL) of diabetes with the main focus on genes and polymorphisms. The major ... Related articles - All 4 versions
H Zhang, WP Wang, T Guo, JC Yang, P Chen, KT … - Journal of Molecular …, 2009 - Elsevier The LIM-homeodomain transcription factor ISL1 (islet factor 1) is essential for pancreatic islet
cell and dorsal mesenchyme development. Mutations in ISL1 are associated with maturity-onset
diabetes of the young and type 2 diabetes. Whether ISL1 plays a role in the insulin gene ... Related articles - All 2 versions
KC Won, JS Yoon - synapse.koreamed.org The adverse effects of prolonged exposure of pancreatic islets to supraphysiologic glucose concentrations
(ie glucose toxicity) is mediated at least in part by glucose oxidation and the subsequent generation
of reactive oxygen species (ROS) that can impair insulin gene expression and β cell ... Related articles - Cached - All 2 versions
