SE Allan, R Broady, S Gregori, ME Himmel, N … - Immunological Reviews, 2008 - pt.wkhealth.com Acknowledgements: We thank Paul Orban for critical reading of the manuscript.
The authors' own research was supported by grants from the Canadian Institutes
for Health Research (CIHR), the National Cancer Institute of Canada, the ... Cited by 22 - Related articles - All 6 versions
- ►jimmunol.org LE Clough, CJ Wang, EM Schmidt, G Booth, … - The Journal of Immunology, 2008 - Am Assoc Immnol The activity of regulatory T cells (Treg) is widely accepted to play a central
role in preventing pathogenic immune responses against self-Ags. However, it is
not clear why such regulation breaks down during the onset of autoimmunity. ... Cited by 17 - Related articles - All 3 versions
AL Christy, MA Brown - The Journal of Immunology, 2007 - Am Assoc Immnol Among the potential outcomes of an aberrantly functioning immune system are
allergic disease and autoimmunity. Although it has been assumed that the
underlying mechanisms mediating these conditions are completely different, ... Cited by 16 - Related articles - All 6 versions
- ►cell.com D Kabelitz, EK Geissler, B Soria, IS Schroeder … - Trends in Immunology, 2008 - Elsevier Type 1 diabetes (T1D) is an autoimmune disease that results from the destruction
of insulin-producing pancreatic islet cells owing to the aggressive effector
function of autoreactive T cells. In addition to lifetime supply of ... Cited by 10 - Related articles - All 4 versions
- ►diabetesjournals.org AL Putnam, TM Brusko, MR Lee, W Liu, GL … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Both CD4 + CD127 lo/− and CD4 + CD127 lo/− CD25 + T-cells could be
expanded and used as Tregs. However, expansion of CD4 + CD127 lo/− cells
required the addition of rapamycin to maintain lineage purity. In contrast, ... Cited by 10 - Related articles - All 4 versions
T Brusko, M Atkinson - Cell biochemistry and biophysics, 2007 - Springer Abstract At the time of this writing, a major void exists; the lack of a method
to prevent and/or reverse type 1 diabetes in humans. We believe this void to a
large extent is the result of our lack in understanding the mechanisms of ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org A Schneider, M Rieck, S Sanda, C Pihoker, … - The Journal of Immunology, 2008 - Am Assoc Immnol Defects in immune regulation have been implicated in the pathogenesis of
diabetes in mouse and in man. In vitro assays using autologous regulatory (Treg)
and responder effector (Teff) T cells have shown that suppression is ... Cited by 9 - Related articles - All 2 versions
T Brusko, J Bluestone - European Journal of Immunology, 2008 - interscience.wiley.com Immune regulation is a complex process that depends on the maintenance of self
tolerance while retaining robust immune responses against microbes. The
emergence of Treg as a central mechanism for immune regulation has ... Cited by 10 - Related articles - BL Direct - All 2 versions
TM Brusko, MA Hulme, CB Myhr, MJ Haller, … - Immunological Investigations, 2007 - informahealthcare.com Regulatory T cells (Treg) play a vital role in controlling peripheral immune
responses in order to prevent autoimmunity and control inflammation. Altered
Treg activities have been associated with the pathogenesis of multiple ... Cited by 8 - Related articles - BL Direct - All 5 versions
Z Vrabelova, Z Hrotekova, Z Hladikova, K … - Scandinavian Journal of Immunology - interscience.wiley.com Abnormalities in CD4 + CD25 + regulatory T cells (Treg) may contribute to type 1
diabetes (T1D) development. First-degree relatives of T1D patients are at
increased risk especially when they carry certain HLA II haplotypes. Using ... Cited by 5 - Related articles - BL Direct - All 4 versions
