J Gudmundsson, P Sulem, V Steinthorsdottir, JT … - Nature genetics, 2007 - nature.com We performed a genome-wide association scan to search for sequence variants conferring risk
of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls.
Follow-up studies involving three additional case-control groups replicated an ... Cited by 188 - Related articles - BL Direct - All 17 versions
- ►diabetesjournals.org M Vaxillaire, J Veslot, C Dina, C Proença, S Cauchi, G … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— The GCK (Glucokinase) −30A allele was associated with increased type 2 diabetes
risk at the end of the follow-up study (adjusted OR 1.34 [95% CI 1.07–1.69]) under an additive
model, as supported in independent French diabetic case subjects (OR 1.22, P = 0.007), ... Cited by 34 - Related articles - BL Direct - All 4 versions
JC Florez - Diabetologia, 2008 - Springer Abstract Although type 2 diabetes has been traditionally understood as a metabolic disorder
initiated by insulin resistance, it has recently become apparent that an impairment in insulin secretion
contributes to its mani- festation and may play a prominent role in its early ... Cited by 31 - Related articles - BL Direct - All 3 versions
H Lango, CNA Palmer, AD Morris, E Zeggini, AT … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVES—Genome-wide association studies have dramatically increased the number of
common genetic variants that are robustly associated with type 2 diabetes. A possible clinical
use of this information is to identify individuals at high risk of developing the disease, so ... Cited by 28 - Related articles - All 5 versions
TM Frayling, MI McCarthy - Diabetologia, 2007 - Springer Page 1. COMMENTARY Genetic studies of diabetes following the advent of the genome-wide
association study: where do we go from here? TM Frayling & MI McCarthy Published online: 25
September 2007 # Springer-Verlag 2007 Keywords Genome-wide association . HHEX . ... Cited by 20 - Related articles - BL Direct - All 2 versions
JRB Perry, TM Frayling - Current Opinion in Clinical Nutrition & …, 2008 - journals.lww.com Recent findings: Recent genome-wide association studies have provided an important resource
for furthering our understanding of type 2 diabetes disease mechanisms. Genes previously unsuspected
of playing a role in diabetes are now implicated in the disease process. These include ... Cited by 17 - Related articles - All 2 versions
- ►diabetesjournals.org J Holmkvist, P Almgren, V Lyssenko, CM Lindgren, KF … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—The polymorphism rs1169288 in HNF-1α strongly predicted future type 2 diabetes
(hazard ratio [HR] 1.2, P = 0.0002). Also, SNPs rs4810424 and rs3212198 in HNF-4α nominally
predicted future type 2 diabetes (HR 1.3 [95% CI 1.0–1.6], P = 0.03; and 1.1 [1.0–1.2], P = ... Cited by 18 - Related articles - All 3 versions
