- ►nih.gov T Nir, DA Melton, Y Dor - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The mechanisms that regulate pancreatic β cell mass are poorly understood. While autoimmune
and pharmacological destruction of insulin-producing β cells is often irreversible, adult β cell
mass does fluctuate in response to physiological cues including pregnancy and insulin ... Cited by 103 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org S Yatoh, R Dodge, T Akashi, A Omer, A Sharma, GC … - Diabetes, 2007 - Am Diabetes Assoc To test whether pancreatic duct cells are in vitro progenitors, they were purified from dispersed
islet-depleted human pancreatic tissue using CA19-9 antibody. The purified fraction was almost
entirely CK19 + with no insulin + cells, whereas the unpurified cells (crude duct) were ... Cited by 42 - Related articles - BL Direct - All 5 versions
G Parnaud, D Bosco, T Berney, F Pattou, J Kerr-Conte, … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis The aim of the study was to determine whether purified beta cells can
replicate in vitro and whether this is enhanced by extracellular matrix (ECM) and growth
factors. Methods Human beta cells were purified by FACS by virtue of their high zinc ... Cited by 38 - Related articles - BL Direct - All 3 versions
- ►alphamedpress.org B Davani, L Ikonomou, BM Raaka, E Geras-Raaka, RA … - Stem Cells, 2007 - AlphaMed Press Islet transplantation offers improved glucose homeostasis in diabetic patients, but transplantation
of islets is limited by the supply of donor pancreases. Undifferentiated precursors hold promise
for cell therapy because they can expand before differentiation to produce a large supply ... Cited by 29 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org HA Russ, Y Bar, P Ravassard, S Efrat - Diabetes, 2008 - Am Diabetes Assoc RESULTS— β-Cells were efficiently and specifically labeled by the dual virus system. Label
+ , insulin − cells derived from β-cells were shown to proliferate for a maximum of 16 population
doublings, with an approximate doubling time of 7 days. Isolated labeled cells could be ... Cited by 20 - Related articles - All 4 versions
S Efrat - Advanced drug delivery reviews, 2008 - Elsevier Beta-cell replacement is considered the optimal treatment for type 1 diabetes, however, it is hindered
by a shortage of human organ donors. Given the difficulty of expanding adult beta cells in
vitro, stem/progenitor cells, which can be expanded in tissue culture and induced to ... Cited by 12 - Related articles - All 4 versions
R Gallo, F Gambelli, B Gava, F Sasdelli, V Tellone … - Cell Death & …, 2007 - nature.com Cellular models and culture conditions for in vitro expansion of insulin-producing cells represent
a key element to develop cell therapy for diabetes. Initial evidence that human -cells could be
expanded after undergoing a reversible epithelial–mesenchymal transition has been ... Cited by 14 - Related articles - BL Direct - All 5 versions
- ►alphamedpress.org CA Fraker, S Alvarez, P Papadopoulos, J Giraldo, W … - Stem Cells, 2007 - AlphaMed Press Despite progress in our knowledge about pancreatic islet specification, most attempts at differentiating
stem/progenitor cells into functional, transplantable β cells have met only with moderate success
thus far. A major challenge is the intrinsic simplicity of in vitro culture systems, which ... Cited by 11 - Related articles - BL Direct - All 6 versions
SC Hanley, A Pilotte, B Massie, L Rosenberg - Laboratory Investigation, 2008 - muhc.ca Cultured human islets can be dedifferentiated to duct-like structures composed mainly of cytokeratinþ
and nestinþ cells. Given that these structures possess the potential to redifferentiate into
islet-like structures, we sought to elucidate their specific cellular origins. Adenoviral ... Cited by 6 - Related articles - View as HTML - All 5 versions
V Sordi, F Bertuzzi, L Piemonti - Regen. Med., 2008 - Future Medicine In both Type 1 and 2 diabetes, insufficient numbers of insulin-producing β-cells are a major cause
of defective control of blood glucose and its complications. Restoration of damaged β-cells by
endocrine pancreas regeneration would be an ideal therapeutic option. The possibility of ... Cited by 5 - Related articles - BL Direct - All 4 versions
