- ►jbc.org S Crunkhorn, F Dearie, C Mantzoros, H Gami, … - Journal of Biological Chemistry, 2007 - ASBMB Peroxisome proliferator activator receptor- coactivator 1 (PGC-1) is a major
candidate gene for diabetes-related metabolic phenotypes, contributing to
decreased expression of nuclear-encoded mitochondrial genes in muscle and ... Cited by 29 - Related articles - All 3 versions
- ►endojournals.org AE Civitarese, E Ravussin - Endocrinology, 2008 - Endocrine Soc MORE THAN 300 million individuals worldwide are projected to be afflicted with
type 2 diabetes mellitus (T2DM) by the year 2025 (1). Other comorbidities that
cluster with diabetes include obesity, dyslipidemia, hypertension, and ... Cited by 11 - Related articles - BL Direct - All 6 versions
- ►endojournals.org J Donkor, LM Sparks, H Xie, SR Smith, K … - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Results: In healthy young men, lipin-1 expression was positively correlated with
insulin sensitivity (R 2 = 0.22; P < 0.01), insulin-stimulated respiratory
quotient (R 2 = 0.16; P < 0.01), and maximal oxygen consumption during ... Cited by 8 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org E Phielix, VB Schrauwen-Hinderling, M … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Insulin-stimulated glucose disposal was lower in diabetic patients
compared with control subjects (11.2 ± 2.8 vs. 28.9 ± 3.7 μmol · kg −1
fat-free mass · min −1 , respectively; P = 0.003), with intermediate ... Cited by 8 - Related articles - All 4 versions
E Phielix, M Mensink - Physiology & Behavior, 2008 - Elsevier Type 2 diabetic patients are characterized by a decreased fat oxidative capacity
and high levels of circulating free fatty acids (FFAs). The latter is known to
cause insulin resistance, in particularly in skeletal muscle, by reducing ... Cited by 7 - Related articles - All 2 versions
- ►physiology.org JE Galgani, C Moro, E Ravussin - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc Metabolic flexibility is the capacity for the organism to adapt fuel oxidation
to fuel availability. The inability to modify fuel oxidation in response to
changes in nutrient availability has been implicated in the accumulation of ... Cited by 7 - Related articles - All 3 versions
- ►nih.gov JE Galgani, LK Heilbronn, K Azuma, DE Kelley … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Compared with nondiabetic subjects, type 2 diabetic subjects are
metabolically inflexible with impaired fasting fat oxidation and impaired
carbohydrate oxidation during a hyperinsulinemic clamp. We hypothesized ... Cited by 6 - Related articles - BL Direct - All 5 versions
- ►endojournals.org [PDF] J Donkor, LM Sparks, H Xie, SR Smith, K … - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Page 1. 1 Adipose tissue lipin-1 expression is correlated with PPARα gene
expression and insulin sensitivity in healthy young men a ... Cited by 4 - Related articles
KA Lê, L Tappy, DA D'Alessio - Current Opinion in Clinical Nutrition & Metabolic Care, 2007 - journals.lww.com Insulin resistance reflects a pathological state defined as blunted responses of
insulin-sensitive organs, such as the liver, adipose tissue or skeletal muscle,
to the usual effects of insulin. Insulin resistance is frequently present ... Cited by 5 - Related articles - BL Direct - All 3 versions
E Corpeleijn, WHM Saris, EE Blaak - Obesity Reviews, 2009 - ki.se Page 1. Etiology and Pathophysiology Metabolic flexibility in the development
of insulin resistance and type 2 diabetes: effects of lifestyle ... Cited by 5 - Related articles - View as HTML - All 5 versions
