MC Alessi, I Juhan-Vague - Thrombosis and haemostasis, 2008 - ncbi.nlm.nih.gov The metabolic syndrome (metS), a concurrence of abdominal fat, disturbed glucose
and insulin metabolism, dyslipidemia, and hypertension has been strongly
associated not only with subsequent development of type 2 diabetes but also ... Cited by 15 - Related articles - BL Direct - All 3 versions
M Barton, M Yanagisawa - Canadian Journal of Physiology and Pharmacology, 2008 - article.pubs.nrc-cnrc.gc.ca Abstract: Since its identification as an endothelial cell-derived
vasoconstrictor peptide in 1988, endothelin-1, the predomi- nant member of the
endothelin peptide family, has received considerable interest in basic ... Cited by 15 - Related articles - All 6 versions
W Bakker, P Sipkema, CDA Stehouwer, EH … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—In the absence of PKC activation, insulin did not alter arterial
diameter, which was caused by a balance of nitric oxide–dependent vasodilator
and endothelin-dependent vasoconstrictor effects. Using three-dimensional ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org D Romualdi, B Costantini, L Selvaggi, M … - Human Reproduction, 2008 - ESHRE BACKGROUND: Metformin was reported to improve the alterations of endothelial
reactivity in normal-weight subjects with polycystic ovary syndrome (PCOS). The
aim of the present study was to investigate the mechanisms of action of ... Cited by 6 - Related articles - All 6 versions
MM Elgebaly, A Kelly, AK Harris, H Elewa, V … - Canadian Journal of Physiology and Pharmacology, 2008 - ingentaconnect.com Abstract: Insulin resistance involves decreased phosphorylation of insulin
receptor substrate (IRS) proteins and (or) Akt. In the vasculature, modulated
Akt phosphorylation may cause impaired vasorelaxation via decreased eNOS ... Cited by 5 - Related articles - All 6 versions
- ►physiology.org AL Mundy, E Haas, I Bhattacharya, CC … - … Journal of Physiology- Regulatory, Integrative and …, 2007 - Am Physiological Soc Reactive oxygen species (ROS) and endothelin-1 (ET-1) contribute to vascular
pathophysiology in obesity. In this context, whether ET-1 modulates hydroxyl
radical ( OH) formation and the function of ROS/ OH in obesity is not ... Cited by 4 - Related articles - BL Direct - All 5 versions
R Muniyappa, M Iantorno, MJ Quon - Endocrinology and metabolism clinics of North America, 2008 - pubmedcentral.nih.gov Endothelial dysfunction and insulin resistance are frequently co-morbid states.
Vasodilator actions of insulin are mediated by phosphatidylinositol 3-kinase
(PI3K)-dependent signaling pathways that stimulate production of nitric ... Cited by 5 - Related articles - All 15 versions
- ►ahajournals.org E Raichlin, A Prasad, V Mathew, B Kent, DR … - Hypertension, 2008 - Am Heart Assoc Endothelin plays an important role in the pathogenesis of atherosclerosis. The
aim of the study was to evaluate the safety and hemodynamic and metabolic
responses to 6 months treatment with atrasentan, the selective endothelin-A ... Cited by 5 - Related articles - All 7 versions
MP Hermans, SA Ahn, D Gruson, MF … - Diabetes & Metabolic Syndrome: Clinical Research & …, 2007 - Elsevier Insulin modulates key regulators of vascular tone, including endothelin-1
(ET-1), hence insulin resistance (IR) and/or hyperinsulinemia may contribute to
the pathogenesis of hypertension and cardiovascular disease (CVD). ... Cited by 3 - Related articles
AA Lteif, AD Fulford, RV Considine, I Gelfand … - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc Endogenous endothelin action is augmented in human obesity and type 2 diabetes
and contributes to endothelial dysfunction and impairs insulin-mediated
vasodilation in humans. We hypothesized that insulin resistance-associated ... Cited by 2 - Related articles - All 3 versions
