N Turner, CR Bruce, SM Beale, KL Hoehn, T So, MS … - Diabetes, 2007 - Am Diabetes Assoc A reduced capacity for mitochondrial fatty acid oxidation in skeletal muscle has been proposed
as a major factor leading to the accumulation of intramuscular lipids and their subsequent deleterious
effects on insulin action. Here, we examine markers of mitochondrial fatty acid oxidative ... Cited by 63 - Related articles - BL Direct - All 5 versions
- ►pnas.org CR Hancock, DH Han, M Chen, S Terada … - Proceedings of the …, 2008 - National Acad Sciences It has been hypothesized that insulin resistance is mediated by a deficiency of mitochondria in
skeletal muscle. In keeping with this hypothesis, high-fat diets that cause insulin resistance have
been reported to result in a decrease in muscle mitochondria. In contrast, we found that ... Cited by 42 - Related articles - BL Direct - All 8 versions
EW Kraegen, GJ Cooney - Current Opinion in Lipidology, 2008 - journals.lww.com Introduction The hypothesis that insulin resistance is related to tri- glyceride accumulation in
muscle and liver dates back to studies of 15–20 years ago showing that triglyceride accumulates
in muscle of high fat-fed rats, coincident with insulin resistance [1,2]. Since then the ... Cited by 25 - Related articles - BL Direct - All 2 versions
- ►cnfindpark.cn JO Holloszy - American Journal of Clinical Nutrition, 2009 - Am Soc Nutrition Patients with type 2 diabetes, insulin-resistant obese individuals, and insulin-resistant offspring
of patients with diabetes have 30% less mitochondria in their skeletal muscles than age-matched
healthy controls. It has been hypothesized that this "deficiency" of mitochondria mediates ... Cited by 19 - Related articles - All 6 versions
N Turner, LK Heilbronn - Trends in Endocrinology & Metabolism, 2008 - Elsevier Insulin resistance is a key defect associated with obesity and type-2 diabetes. The precise factors
that lead to insulin resistance have not been elucidated fully, but there is a strong association
between insulin resistance and inappropriate lipid accumulation in insulin-target tissues. ... Cited by 13 - Related articles - All 5 versions
- ►cnfindpark.cn GP Holloway, A Bonen, LL Spriet - American Journal of Clinical …, 2009 - ajcn.cnfindpark.cn A reduction in fatty acid (FA) oxidation has been associated with lipid accumulation and insulin
resistance in skeletal muscle of obese individuals. Numerous reports suggest that the reduction
in FA oxidation may result from intrinsic mitochondrial defects, although little direct ... Cited by 7 - Related articles - All 6 versions
H Vosper - British Journal of Pharmacology, 2009 - interscience.wiley.com Dyslipidaemias, particularly those characterized by the 'atherogenic profile' of high low-density
lipoprotein-cholesterol and triglycerides and low high-density lipoprotein-cholesterol, are the
major modifiable risk factor for atherosclerosis. The search for drugs to favourably alter ... Cited by 1 - Related articles - All 3 versions
B Salgin, ML Marcovecchio, RM Williams, SJ … - Journal of Clinical …, 2009 - Endocrine Soc Patients: Seven (four females, three males) nonobese patients with T1D aged 21–30 yr were
studied on four occasions in random order. On each visit, overnight endogenous GH production
was suppressed by octreotide. Three 1-h pulses of recombinant human GH (rhGH) or ... Related articles - All 3 versions
N Turner, CR Bruce, SM Beale, KL Hoehn, T So, MS … - DIABETES, 2007 - Am Diabetes Assoc A reduced capacity for mitochondrial fatty acid oxidation in skeletal muscle has been proposed
as a major factor leading to the accumulation of intramuscular lipids and their subsequent deleterious
effects on insulin action. Here, we examine markers of mitochondrial fatty acid oxidative ... Related articles - All 2 versions
SS Chen, TS Santomango, PE Williams, … - American Journal of …, 2009 - Am Physiological Soc Glucose, fat, and glucagon availability are increased in diabetes. The normal response of the
liver to chronic increases in glucose availability is to adapt to become a marked consumer of
glucose. Yet this fails to occur in diabetes. The aim was to determine whether increased ... Related articles - All 3 versions