- ►ahajournals.org Z Xie, Y Dong, R Scholz, D Neumann, MH … - Circulation, 2008 - Am Heart Assoc Methods and Results— Exposure of human umbilical vein endothelial cells or
bovine aortic endothelial cells to metformin significantly increased AMPK
activity and the phosphorylation of both AMPK at Thr172 and LKB1 at Ser428, ... Cited by 36 - Related articles - All 3 versions
DG Hardie - FEBS letters, 2008 - Elsevier Obesity, type 2 diabetes and the metabolic syndrome are disorders of energy
balance, which the AMP-activated protein kinase (AMPK) regulates both at the
cellular and whole body levels. AMPK switches cells from an anabolic state ... Cited by 31 - Related articles - All 11 versions
EW Kraegen, GJ Cooney - Current Opinion in Lipidology, 2008 - journals.lww.com Introduction The hypothesis that insulin resistance is related to tri- glyceride
accumulation in muscle and liver dates back to studies of 15–20 years ago
showing that triglyceride accumulates in muscle of high fat-fed rats, ... Cited by 25 - Related articles - BL Direct - All 2 versions
- ►physiology.org K Sakamoto, GD Holman - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc Vesicular traffic of the glucose transporter GLUT4 occurs in response to
insulin, muscle contraction, and metabolic stimuli that lead to changes in the
energy status of the cell. These stimuli are associated with linked kinase ... Cited by 22 - Related articles - All 6 versions
- ►fasebj.org P de Lange, M Moreno, E Silvestri, A Lombardi … - The FASEB Journal, 2007 - FASEB Energy deprivation poses a tremendous challenge to skeletal muscle. Glucose
(ATP) depletion causes muscle fibers to undergo rapid adaptive changes toward
the use of fatty acids (instead of glucose) as fuel. Physiological ... Cited by 19 - Related articles - BL Direct - All 4 versions
- ►physiology.org AS Mathai, A Bonen, CR Benton, DL … - Journal of Applied Physiology, 2008 - Am Physiological Soc The mRNA of the nuclear coactivator peroxisome proliferator-activated receptor-
coactivator-1 (PGC-1 ) increases during prolonged exercise and is influenced by
carbohydrate availability. It is unknown if the increases in mRNA reflect ... Cited by 17 - Related articles - All 3 versions
- ►physiology.org E De Filippis, G Alvarez, R Berria, K Cusi, S … - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc Mitochondrial dysfunction, associated with insulin resistance, is characterized
by low expression of peroxisome proliferator-activated receptor- coactivator-1
(PGC-1 ) and nuclear-encoded mitochondrial genes. This deficit could be due ... Cited by 14 - Related articles - BL Direct - All 3 versions
- ►nih.gov CQ Lai, KL Tucker, LD Parnell, X Adiconis, B … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Individuals with type 2 diabetes exhibit higher DNA damage and
increased risk of cardiovascular disease (CVD). However, mechanisms underlying
the association between DNA damage and development of type 2 diabetes and ... Cited by 12 - Related articles - BL Direct - All 13 versions
- ►physiology.org KF Howlett, A Mathews, A Garnham, K … - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc AS160 is an Akt substrate of 160 kDa implicated in the regulation of both
insulin- and contraction-mediated GLUT4 translocation and glucose uptake. The
effects of aerobic exercise and subsequent insulin stimulation on AS160 ... Cited by 10 - Related articles - BL Direct - All 3 versions
HJ Koh, J Brandauer, LJ Goodyear - Current Opinion in Clinical Nutrition & Metabolic Care, 2008 - journals.lww.com Introduction The AMP-activated protein kinase (AMPK) was first identified as a
Ser/Thr kinase that inactivates key enzymes involved in lipid and cholesterol
biosynthesis [1]. In skeletal muscle, several lines of evidence support a ... Cited by 9 - Related articles - BL Direct - All 3 versions
