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Scholar Results 1 - 10 of about 15 citing Speier: Cx36-mediated coupling reduces β-cell heterogeneity, confines the stimulating glucose.... (0.08 sec) 

Beta cells preferentially exchange cationic molecules via connexin 36 gap junction …


E Charpantier, J Cancela, P Meda - Diabetologia, 2007 - Springer
Abstract Aims/hypothesis Pancreatic beta cells are connected by gap junction channels made
of connexin 36 (Cx36), which permit intercellular exchanges of current-carrying ions (ionic
coupling) and other molecules (metabolic coupling). Previ- ous studies have suggested ...
Cited by 10 - Related articles - BL Direct - All 2 versions

Ca2+-secretion coupling is impaired in diabetic Goto Kakizaki rats

- rupress.org
T Rose, S Efendic, M Rupnik - Journal of General Physiology, 2007 - jgp.rupress.org
The Goto Kakizaki (GK) rat is a widely used animal model to study defective glucose-stimulated
insulin release in type-2 diabetes (T2D). As in T2D patients, the expression of several proteins
involved in Ca 2+ -dependent exocytosis of insulin-containing large dense-core vesicles ...
Cited by 10 - Related articles - BL Direct - All 5 versions

Islet-cell-to-cell communication as basis for normal insulin secretion


S Bavamian, P Klee, A Britan, C Populaire, D … - Diabetes Obes …, 2007 - interscience.wiley.com
The emergence of pancreatic islets has necessitated the development of a signalling system
for the intra- and inter-islet coordination of β cells. With evolution, this system has evolved into
a complex regulatory network of partially cross-talking pathways, whereby individual cells ...
Cited by 6 - Related articles - All 2 versions

A new conditional mouse mutant reveals specific expression and functions of …


K Wellershaus, J Degen, J Deuchars, M Theis, A … - Experimental Cell …, 2008 - Elsevier
Connexin36 (Cx36) is the main connexin isoform expressed in neurons of the central nervous
system (CNS) and in pancreatic β-cells, ie two types of excitable cells that share – in spite of
their different origins – a number of common features. Previous studies on Cx36 deficient ...
Cited by 3 - Related articles - All 2 versions

Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion

- endojournals.org
F Jaques, H Jousset, A Tomas, AL Prost, CB Wollheim, … - Endocrinology, 2008 - Endocrine Soc
Cell-to-cell interactions play an important role in insulin secretion. Compared with intact
islets, dispersed pancreatic β-cells show increased basal and decreased glucose-stimulated
insulin secretion. In this study, we used mouse MIN6B1 cells to investigate the ...
Cited by 3 - Related articles - BL Direct - All 3 versions

Cx36 makes channels coupling human pancreatic {beta}-cells, and correlates with …


V Serre-Beinier, D Bosco, L Zulianello, A … - Human Molecular …, 2009 - Oxford Univ Press
Previous studies have documented that the insulin-producing β-cells of laboratory rodents are
coupled by gap junction channels made solely of the connexin36 (Cx36) protein, and have shown
that loss of this protein desynchronizes β-cells, leading to secretory defects reminiscent of ...
Cited by 2 - Related articles - All 3 versions

ICER-1γ Overexpression Drives Palmitate-mediated Connexin36 Down-regulation …


F Allagnat, F Alonso, D Martin, A Abderrahmani, G … - Journal of Biological …, 2008 - ASBMB
Channels formed by the gap junction protein connexin36 (Cx36) contribute to the proper control
of insulin secretion. We investigated the impact of chronic hyperlipidemia on Cx36 expression
in pancreatic β-cells. Prolonged exposure to the saturated free fatty acid palmitate ...
Cited by 2 - Related articles - All 3 versions

Lack of “Hemichannel” Activity in Insulin-Producing Cells


E Scemes, S Bavamian, A Charollais, DC … - Cell communication …, 2008 - pubmedcentral.nih.gov
Connexins and pannexins have been implicated in the formation of “hemichannels,” which may
account for the uptake and release of membrane-impermeant molecules in single cells. The
in vivo existence of “hemichannels” and their protein composition is still debated. ...
Cited by 2 - Related articles - All 6 versions

7. Gap Junctions and Insulin Secretion


P Klee, S Bavamian, A Charollais, D Caille, J … - Pancreatic Beta Cell in …, 2007 - Springer
Summary. About 30 years ago, pancreatic beta cells were shown to be con- nected by gap junctions
and to exhibit glucose-induced oscillatory electrical activity, two features that were hypothetically
linked to insulin secretion. Since then, gap junctions have been shown to be an obligatory ...
Related articles - All 2 versions

Ca2 $# x0002b; $# x02013; Secretion Coupling Is Impaired in Diabetic Goto …


T Rose, S Efendic, M Rupnik - The Journal of General Physiology, 2007 - ukpmc.ac.uk
The Goto Kakizaki (GK) rat is a widely used animal model to study defective glucose-stimulated
insulin release in type-2 diabetes (T2D). As in T2D patients, the expression of several proteins
involved in Ca 2+ -dependent exocytosis of insulin-containing large dense-core vesicles ...
Related articles


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