- ►endojournals.org V Poitout, RP Robertson - Endocrine reviews, 2008 - Endocrine Soc Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that
are proposed to play a role in all forms of type 2 diabetes. The underlying
concept is that once the primary pathogenesis of diabetes is established, ... Cited by 68 - Related articles - BL Direct - All 7 versions
- ►jbc.org CS Sum, IG Tikhonova, S Neumann, S Engel, … - Journal of Biological Chemistry, 2007 - ASBMB GPR40 was formerly an orphan G protein-coupled receptor whose endogenous ligands
have recently been identified as free fatty acids (FFAs). The receptor, now
named FFA receptor 1, has been implicated in the pathophysiology of type 2 ... Cited by 17 - Related articles - All 6 versions
- ►diabetesjournals.org CP Tan, Y Feng, YP Zhou, GJ Eiermann, A … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Acute activation of G protein–coupled receptor 40 (GPR40) by free
fatty acids (FFAs) or synthetic GPR40 agonists enhances insulin secretion.
However, it is still a matter of debate whether activation of GPR40 would ... Cited by 17 - Related articles - All 5 versions
S Edfalk, P Steneberg, H Edlund - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—The G-protein–coupled receptor Gpr40 is expressed in β-cells
where it contributes to free fatty acid (FFA) enhancement of glucose-stimulated
insulin secretion (1–4). However, other sites of Gpr40 expression, ... Cited by 15 - Related articles - All 4 versions
- ►jbc.org JW Joseph, ML Odegaard, SM Ronnebaum, SC … - Journal of Biological Chemistry, 2007 - ASBMB It has been proposed that de novo synthesis of long-chain acyl-CoA (LC-CoA) is a
signal for glucose-stimulated insulin secretion (GSIS). Key enzymes involved in
synthesis of fatty acids from glucose include ATP-citrate lyase (CL) and ... Cited by 15 - Related articles - All 4 versions
M Kebede, T Alquier, MG Latour, M Semache, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—The G-protein–coupled receptor GPR40 is expressed in pancreatic
β-cells and is activated by long-chain fatty acids. Gene deletion studies have
shown that GPR40 mediates, at least in part, fatty acid–amplification of ... Cited by 13 - Related articles - All 4 versions
H Lan, LM Hoos, L Liu, G Tetzloff, W Hu, SJ … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—FFAR1/GPR40 is a G-protein–coupled receptor expressed
predominantly in pancreatic islets mediating free fatty acid–induced insulin
secretion. However, the physiological role of FFAR1 remains controversial. ... Cited by 9 - Related articles - All 5 versions
A Hirasawa, T Hara, S Katsuma, T Adachi, G … - Biological & Pharmaceutical Bulletin, 2008 - J-STAGE Free fatty acids (FFAs) are not only essential nutritional components but
contribute to many cellular functions. By co- ordinating the expression of
proteins involved in lipid uptake, synthesis, transport, storage, ... Cited by 9 - Related articles - All 2 versions
- ►pubget.com [PDF] LA Stoddart, NJ Smith, G Milligan - Pharmacological reviews, 2008 - ASPET Identification of G protein-coupled receptors that are activated by free fatty
acids has led to considerable interest in their pharmacology and function
because of the wide range of normal physiology and disease states in which ... Cited by 9 - Related articles - All 5 versions
S Costanzi, S Neumann, MC Gershengorn - Journal of Biological Chemistry, 2008 - ASBMB Free fatty acids (FFAs) 2 take part in many physiological processes in different
tissues such as skeletal muscle, liver, heart, and pancreas by providing an
oxidative energy source. In addition, FFAs are potent signaling molecules ... Cited by 9 - Related articles - All 6 versions
