CE Lowe, JD Cooper, T Brusko, NM Walker, DJ … - Nature - diabetes.ufl.edu Genome-wide association studies are now identifying disease-associated
chromosome regions. However, even after convincing replication, the localization
of the causal variant(s) requires comprehensive resequencing, extensive ... Cited by 97 - Related articles - View as HTML - BL Direct - All 10 versions
- ►diabetesjournals.org H Hakonarson, HQ Qu, JP Bradfield, L … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—In stage 1 of our genome-wide association (GWA) study for type 1
diabetes, one locus at 16p13 was detected (P = 1.03 × 10 −10 ) and confirmed
in two additional cohorts. Here we describe the results of testing, in ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org DJ Smyth, JD Cooper, JMM Howson, NM Walker … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—The disease association of the common 1858C>T Arg620Trp (rs2476601)
nonsynonymous single nucleotide polymorphism (SNP) of protein tyrosine
phosphatase; nonreceptor type 22 (PTPN22) on chromosome 1p13 has been ... Cited by 16 - Related articles - All 4 versions
- ►nih.gov BL Browning, SR Browning - Human genetics, 2008 - Springer Abstract We applied a recently developed multilocus association testing method
(localized haplotype clustering) to Wellcome Trust Case Control Consortium data
(14,000 cases of seven common diseases and 3,000 shared controls genotyped ... Cited by 14 - Related articles - All 5 versions
- ►cell.com H Ounissi-Benkalha, C Polychronakos - Trends in Molecular Medicine, 2008 - Elsevier Susceptibility to type 1 diabetes (T1D) is determined by complex interactions
between several genetic loci and environmental factors. Alleles at the human
leukocyte antigen (HLA) locus explain up to 50% of the familial clustering ... Cited by 13 - Related articles - All 4 versions
LM Maier, CE Lowe, J Cooper, K Downes, DE … - PLoS Genetics, 2009 - pubmedcentral.nih.gov Multiple sclerosis (MS) and type 1 diabetes (T1D) are organ-specific autoimmune
disorders with significant heritability, part of which is conferred by shared
alleles. For decades, the Human Leukocyte Antigen (HLA) complex was the ... Cited by 12 - Related articles - All 5 versions
SFA Grant, HQ Qu, JP Bradfield, L Marchand, … - Diabetes, 2009 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—From our existing datasets, we selected 982
markers with P < 0.05 in both GWA cohorts. Genotyping these in an independent
set of 636 nuclear families with 974 affected offspring revealed 75 markers ... Cited by 7 - Related articles - All 3 versions
- ►jimmunol.org E Sgouroudis, A Albanese, CA Piccirillo - The Journal of Immunology, 2008 - Am Assoc Immnol Type I diabetes (T1D) susceptibility is inherited through multiple
insulin-dependent diabetes (Idd) genes. NOD.B6 Idd3 congenic mice, introgressed
with an Idd3 allele from T1D-resistant C57BL/6 mice (Idd3 B6 ), show a ... Cited by 6 - Related articles - All 2 versions
DL Duffy - Current Opinion in Allergy and Clinical Immunology, 2007 - journals.lww.com Purpose of review: I discuss the increasing number of genes discovered to exert
pleiotropic action on susceptibility to diabetes and simultaneously to other
immune-mediated diseases. While a genetic correlation between type 1 ... Cited by 5 - Related articles - All 3 versions
