- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis
of diabetes, contributing to pancreatic β-cell loss and insulin resistance. Components of the unfolded
protein response (UPR) play a dual role in β-cells, acting as beneficial regulators under ... Cited by 93 - Related articles - BL Direct - All 5 versions
- ►jlr.org MF Gregor, GS Hotamisligil - The Journal of Lipid Research, 2007 - ASBMB In the context of obesity and its related maladies, the adipocyte plays a central role in the
balance, or imbalance, of metabolic homeostasis. An obese, hypertrophic adipocyte is challenged
by many insults, including surplus energy, inflammation, insulin resistance, and ... Cited by 78 - Related articles - All 5 versions
- ►clinchem.org S de Ferranti, D Mozaffarian - Clinical chemistry, 2008 - Am Assoc Clin Chem Content: In this report we review adipocyte metabolism and function in the context of energy
imbalance and postprandial nutrient excess, including adipocyte hypertrophy and
hyperplasia, adipocyte dysfunction, and other systemic consequences. We also discuss ... Cited by 50 - Related articles - BL Direct - All 5 versions
S Schenk, M Saberi, JM Olefsky - The Journal of Clinical …, 2008 - pubmedcentral.nih.gov Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of
a number of diseases, including type 2 diabetes. In this review, we discuss potential mechanisms
by which brief nutrient excess and obesity lead to insulin resistance and propose that ... Cited by 47 - Related articles - All 12 versions
- ►endojournals.org N Rasouli, PA Kern - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Context: Adipose tissue is increasingly recognized as an active endocrine organ with many secretory
products and part of the innate immune system. With obesity, macrophages infiltrate adipose
tissue, and numerous adipocytokines are released by both macrophages and adipocytes. ... Cited by 40 - Related articles - All 3 versions
P Trayhurn, B Wang, IS Wood - British Journal of Nutrition, 2008 - Cambridge Univ Press White adipose tissue is a key endocrine and secretory organ, releasing multiple adipokines,
many of which are linked to inflammation and immu- nity. During the expansion of adipose tissue
mass in obesity there is a major inflammatory response in the tissue with increased ... Cited by 41 - Related articles - All 3 versions
GH Goossens - Physiology & Behavior, 2008 - Elsevier Research of the past decade has increased our understanding of the role adipose tissue plays
in health and disease. Adipose tissue is now recognized as a highly active metabolic and endocrine
organ. Adipocytes are of importance in buffering the daily influx of dietary fat and exert ... Cited by 37 - Related articles - All 4 versions
LK Heilbronn, LV Campbell - Current Pharmaceutical Design, 2008 - ingentaconnect.com Abstract: Obesity was first described as a low-grade inflammatory condition more than a decade
ago. However, it is only relatively re- cently that obese individuals have been described with
increased macrophage infiltration of adipose tissue, as well as an increase in the number ... Cited by 36 - Related articles - BL Direct - All 2 versions
GR Hajer, TW van Haeften, FLJ Visseren - European Heart Journal, 2008 - Eur Soc Cardiology The increased prevalence of excessive visceral obesity and obesity-related cardiovascular risk
factors is closely associated with the rising incidence of cardiovascular diseases and type 2 diabetes
mellitus. This clustering of vascular risk factors in (visceral) obesity is often referred to as ... Cited by 34 - Related articles - All 4 versions
SA Shore - The Journal of Allergy and Clinical Immunology, 2008 - Elsevier Epidemiologic data indicate that obesity increases the prevalence and incidence of asthma and
reduces asthma control. Obese mice exhibit innate airway hyperresponsiveness and augmented
responses to certain asthma triggers, further supporting a relationship between obesity ... Cited by 35 - Related articles - All 40 versions
