- ►pnas.org K Kabayama, T Sato, K Saito, N Loberto, A … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Membrane microdomains (lipid rafts) are now recognized as critical for proper
compartmentalization of insulin signaling. We previously demonstrated that, in
adipocytes in a state of TNFα-induced insulin resistance, the inhibition ... Cited by 33 - Related articles - BL Direct - All 6 versions
- ►endojournals.org WL Holland, SA Summers - Endocrine Reviews, 2008 - Endocrine Soc Obesity and dyslipidemia are risk factors for metabolic disorders including
diabetes and cardiovascular disease. Sphingolipids such as ceramide and
glucosylceramides, while being a relatively minor component of the lipid ... Cited by 29 - Related articles - All 7 versions
- ►uva.nl [PDF] K Ghauharali-van der Vlugt, M Langeveld, A … - Clinica Chimica Acta, 2007 - Elsevier The ceramide concentration in plasma of untreated Gaucher patients was slightly
but not significantly lower than in controls (median: 9.8 µmol/L, range:
5.7–14.7 µmol/L, (n = 40) vs. median: 11.0 µmol/L, range: 5.1–18.0 ... Cited by 13 - Related articles - All 3 versions
MS Macauley, AK Bubb, C Martinez-Fleites, … - Journal of Biological Chemistry, 2008 - ASBMB The O-GlcNAc post-translational modification is considered to act as a sensor of
nutrient flux through the hexosamine biosynthetic pathway. A cornerstone of this
hypothesis is that global elevation of protein O-GlcNAc levels, typically ... Cited by 11 - Related articles - All 3 versions
- ►endojournals.org M Langeveld, KJM Ghauharali, HP Sauerwein, … - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Context: Complex glycosphingolipids, in majority the ganglioside GM3, surround
the insulin receptor in a special membrane compartment (raft) and modulate
signaling through this receptor. Increased levels of GM3 in rafts impair ... Cited by 8 - Related articles - All 5 versions
V Poitout, J Amyot, M Semache, B Zarrouki, D … - BBA-Molecular and Cell Biology of Lipids, 2009 - Elsevier The concept of glucolipotoxicity refers to the combined, deleterious effects of
elevated glucose, and fatty acid levels on pancreatic beta-cell function and
survival. Significant progress has been made in recent years towards a ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►nih.gov M Bogdanov, E Mileykovskaya, W Dowhan - Subcell Biochem, 2008 - Springer Abstract Lipids play important roles in cellular dysfunction leading to disease.
Although a major role for phospholipids is in defining the membrane perme-
ability barrier, phospholipids play a central role in a diverse range of ... Cited by 8 - Related articles - All 4 versions
KA McEachern, J Fung, S Komarnitsky, CS … - Molecular genetics and metabolism, 2007 - Elsevier An approach to treating Gaucher disease is substrate inhibition therapy which
seeks to abate the aberrant lysosomal accumulation of glucosylceramide. We have
identified a novel inhibitor of glucosylceramide synthase (Genz-112638) and ... Cited by 10 - Related articles - All 4 versions
M van Eijk, J Aten, N Bijl, R Ottenhoff, … - PLoS One, 2009 - pubmedcentral.nih.gov Adipose tissue is a critical mediator in obesity-induced insulin resistance.
Previously we have demonstrated that pharmacological lowering of
glycosphingolipids and subsequently GM3 by using the iminosugar AMP-DNM, ... Cited by 7 - Related articles - All 6 versions
Y Hirabayashi, S Furuya - Progress in Lipid Research, 2008 - Elsevier Sphingolipids represent a class of membrane lipids that contain a hydrophobic
ceramide chain as its common backbone structure. Sphingolipid synthesis requires
two simple components: l-serine and palmitoyl CoA. Although l-serine is ... Cited by 7 - Related articles - All 2 versions
