- ►nih.gov T Nir, DA Melton, Y Dor - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The mechanisms that regulate pancreatic β cell mass are poorly understood.
While autoimmune and pharmacological destruction of insulin-producing β cells
is often irreversible, adult β cell mass does fluctuate in response to ... Cited by 101 - Related articles - BL Direct - All 8 versions
M Stadtfeld, K Brennand, K Hochedlinger - Current Biology, 2008 - Elsevier Induced pluripotent stem (iPS) cells have been derived from fibroblast, stomach,
and liver cultures at extremely low frequencies by ectopic expression of the
transcription factors Oct4, Sox2, c-myc, and Klf4, a process coined direct ... Cited by 64 - Related articles - All 5 versions
- ►diabetesjournals.org S Yatoh, R Dodge, T Akashi, A Omer, A … - Diabetes, 2007 - Am Diabetes Assoc To test whether pancreatic duct cells are in vitro progenitors, they were
purified from dispersed islet-depleted human pancreatic tissue using CA19-9
antibody. The purified fraction was almost entirely CK19 + with no insulin ... Cited by 40 - Related articles - BL Direct - All 5 versions
G Parnaud, D Bosco, T Berney, F Pattou, J … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis The aim of the study was to determine whether purified
beta cells can replicate in vitro and whether this is enhanced by extracellular
matrix (ECM) and growth factors. Methods Human beta cells were purified by ... Cited by 38 - Related articles - BL Direct - All 3 versions
- ►alphamedpress.org B Davani, L Ikonomou, BM Raaka, E Geras- … - Stem Cells, 2007 - AlphaMed Press Islet transplantation offers improved glucose homeostasis in diabetic patients,
but transplantation of islets is limited by the supply of donor pancreases.
Undifferentiated precursors hold promise for cell therapy because they can ... Cited by 29 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org HA Russ, Y Bar, P Ravassard, S Efrat - Diabetes, 2008 - Am Diabetes Assoc RESULTS— β-Cells were efficiently and specifically labeled by the dual virus
system. Label + , insulin − cells derived from β-cells were shown to
proliferate for a maximum of 16 population doublings, with an approximate ... Cited by 19 - Related articles - All 4 versions
S Efrat - Advanced drug delivery reviews, 2008 - Elsevier Beta-cell replacement is considered the optimal treatment for type 1 diabetes,
however, it is hindered by a shortage of human organ donors. Given the
difficulty of expanding adult beta cells in vitro, stem/progenitor cells, ... Cited by 12 - Related articles - All 4 versions
R Gallo, F Gambelli, B Gava, F Sasdelli, V … - Cell Death & Differentiation, 2007 - nature.com Cellular models and culture conditions for in vitro expansion of
insulin-producing cells represent a key element to develop cell therapy for
diabetes. Initial evidence that human -cells could be expanded after ... Cited by 13 - Related articles - BL Direct - All 5 versions
SC Hanley, A Pilotte, B Massie, L Rosenberg - Laboratory Investigation, 2008 - muhc.ca Cultured human islets can be dedifferentiated to duct-like structures composed
mainly of cytokeratinþ and nestinþ cells. Given that these structures possess
the potential to redifferentiate into islet-like structures, we sought to ... Cited by 6 - Related articles - View as HTML - All 5 versions
V Sordi, F Bertuzzi, L Piemonti - Regen. Med., 2008 - Future Medicine In both Type 1 and 2 diabetes, insufficient numbers of insulin-producing
β-cells are a major cause of defective control of blood glucose and its
complications. Restoration of damaged β-cells by endocrine pancreas ... Cited by 5 - Related articles - BL Direct - All 4 versions
