- ►uniba.it [PDF] IR Mackay, NV Leskovsek, NR Rose - Journal of Autoimmunity, 2008 - Elsevier Inflammation has close clinico-pathologic associations with autoimmunity, but
future analyses will require better definition and metrics of inflammation,
particularly for the earliest cellular and molecular components dependent ... Cited by 42 - Related articles - All 4 versions
S Marzorati, A Pileggi, C Ricordi - Expert Opin. Biol. Ther., 2007 - informahealthcare.com Significant progress has been made in the field of β-cell replacement therapies
by islet transplantation in patients with unstable Type 1 diabetes mellitus
(T1DM). Recent clinical trials have shown that islet transplantation can ... Cited by 11 - Related articles - BL Direct - All 6 versions
- ►pnas.org M Koulmanda, M Bhasin, L Hoffman, Z Fan, A … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Invasive insulitis is a destructive T cell-dependent autoimmune process directed
against insulin-producing β cells that is central to the pathogenesis of type 1
diabetes mellitus (T1DM) in humans and the clinically relevant nonobese ... Cited by 5 - Related articles - All 5 versions
- ►pnas.org EC Lewis, M Mizrahi, M Toledano, N DeFelice, … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Human pancreatic islet transplantation offers diabetic patients tight glucose
control but has low graft survival rates. The immunosuppressive drugs that are
administered to graft recipients lack the antiinflammatory benefits of ... Cited by 5 - Related articles - All 8 versions
NV Leskovek, IR Mackay, NR Rose - Journal of autoimmunity, 2008 - pubmedcentral.nih.gov Inflammation has close clinico-pathologic associations with autoimmunity, but
future analyses will require better definition and metrics of inflammation,
particularly for the earliest cellular and molecular components dependent ... Cited by 3 - Related articles
CS Sandström, B Ohlsson, O Melander, U … - Diabet. Med, 2008 - omnibiopharma.com Aims α1-Antitrypsin (AAT) is a serine protease inhibitor which recently has
been shown to prevent Type 1 diabetes development, to prolong islet allograft
survival and to inhibit pancreatic B-cell apoptosis in vivo. It has also ... Cited by 1 - Related articles - View as HTML - All 4 versions
GC Weir, M Koulamnda - Current Diabetes Reports, 2009 - Springer Controlling immune destruction of pancreatic β cells is a critically important
challenge for diabetes research. The study of mechanisms of autoimmunity in type
1 diabetes and the rejection of transplanted islets has focused on the ... Cited by 2 - Related articles - All 2 versions
Y Lu, M Parker, A Pileggi, B Zhang, YK Choi, … - Clinical and Experimental Immunology, 2008 - pubmedcentral.nih.gov Previous studies have shown that human alpha-1 antitrypsin (hAAT) gene delivery
prevents type 1 diabetes (T1D) in non-obese diabetic (NOD) mice. Furthermore,
hAAT protein administration prolongs acceptance of islet allografts. ... Cited by 1 - Related articles - All 5 versions
RD Molano, A Pileggi, S Song, E Zahr, S San … - Transplantation Proceedings, 2008 - mac.com ABSTRACT Immunomodulatory properties have been recognized for human alpha-1
antitrypsin (hAAT). However, production of anti-hAAT antibodies in mice may
inactivate the protein. In this study, we evaluated the effects of chronic ... Cited by 1 - Related articles - View as HTML - All 10 versions
M Campbell-Thompson, LR Dixon, C … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Recent histological analysis of pancreases obtained
from patients with long-standing type 1 diabetes identified chronic islet
inflammation and limited evidence suggestive of beta cell replication. ... Cited by 1 - Related articles - All 3 versions
