- ►shouxi.net C Huang, C Lin, L Haataja, T Gurlo, AE Butler, RA … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Endoplasmic reticulum (ER) stress–induced apoptosis may be a common cause
of cell attrition in diseases characterized by misfolding and oligomerisation of amyloidogenic
proteins. The islet in type 2 diabetes is characterized by islet amyloid derived from islet ... Cited by 56 - Related articles - BL Direct - All 5 versions
- ►endojournals.org L Haataja, T Gurlo, CJ Huang, PC Butler - Endocrine Reviews, 2008 - Endocrine Soc Type 2 diabetes (T2DM) is characterized by insulin resistance, defective insulin secretion, loss
of β-cell mass with increased β-cell apoptosis and islet amyloid. The islet amyloid is derived
from islet amyloid polypeptide (IAPP, amylin), a protein coexpressed and cosecreted with ... Cited by 28 - Related articles - BL Direct - All 4 versions
G Habicht, C Haupt, RP Friedrich, P … - Proceedings of the …, 2007 - National Acad Sciences The formation of amyloid fibrils is a common biochemical characteristic that occurs in Alzheimer's
disease and several other amyloidoses. The unifying structural feature of amyloid fibrils is their
specific type of β-sheet conformation that differentiates these fibrils from the products of ... Cited by 19 - Related articles - BL Direct - All 7 versions
- ►physiology.org C Huang, L Haataja, T Gurlo, AE Butler, X … - American Journal of …, 2007 - Am Physiological Soc The islet in type 2 diabetes is characterized by an 60% β-cell deficit, increased β-cell
apoptosis, and islet amyloid derived from islet amyloid polypeptide (IAPP). Human IAPP
(hIAPP) but not rodent IAPP (rIAPP) forms toxic oligomers and amyloid fibrils in an ... Cited by 10 - Related articles - BL Direct - All 3 versions
K Lucie… - Experimental Diabetes Research, 2008 - hindawi.com The presence of fibrillar protein deposits (amyloid) of human islet amyloid polypeptide
(hIAPP) in the pancreatic islets of Langerhans is thought to be related to death of the
insulin-producing islet β -cells in type 2 diabetes mellitus (DM2). The mechanism of ... Cited by 8 - Related articles - Cached - All 8 versions
- ►diabetesjournals.org S Zhang, H Liu, H Yu, GJS Cooper - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS— We measured responses to hA in isolated mouse islets
and two insulinoma cell lines, wherein we measured Fas/Fas ligand (FasL) and Fas-associated
death domain (FADD) expression by quantitative RT-PCR, Western blotting, and ... Cited by 5 - Related articles - BL Direct - All 3 versions
R Mishra, B Bulic, D Sellin, S Jha, H … - Angew Chem Int Ed …, 2008 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 4 - Related articles - All 3 versions
S Bonner-Weir, TD O'Brien - Diabetes, 2008 - Am Diabetes Assoc The UK Prospective Diabetes Study (UKPDS) orchestrated by Robert Turner showed that, even
with treatment, in type 2 diabetes a progressive β-cell dysfunction in a large number of patients
was seen with the eventual need for additional oral antihyperglycemic medication and ... Cited by 3 - Related articles - All 3 versions
WQ Zhao, PN Lacor, H Chen, MP Lambert, … - Journal of Biological …, 2009 - muse.lib.nchu.edu.tw Accumulation of amyloid β (Aβ) oligomers in the brain is toxic to synapses and may play an important
role in memory loss in Alzheimer disease. However, how these toxins are built up in the brain
is not understood. In this study we investigate whether impairments of insulin and ... Cited by 2 - Related articles - All 5 versions
