- ►jlr.org JK Sethi, AJ Vidal-Puig - The Journal of Lipid Research, 2007 - ASBMB This review focuses on adipose tissue biology and introduces the concept of adipose tissue plasticity
and expandability as key determinants of obesity-associated metabolic dysregulation. This concept
is fundamental to our understanding of adipose tissue as a dynamic organ at the center of ... Cited by 54 - Related articles - All 4 versions
WP Cawthorn, JK Sethi - FEBS letters, 2008 - Elsevier Dyslipidemia and insulin resistance are commonly associated with catabolic or lipodystrophic
conditions (such as cancer and sepsis) and with pathological states of nutritional overload (such
as obesity-related type 2 diabetes). Two common features of these metabolic disorders ... Cited by 40 - Related articles - All 12 versions
- ►pnas.org K Kabayama, T Sato, K Saito, N Loberto, … - Proceedings of the …, 2007 - National Acad Sciences Membrane microdomains (lipid rafts) are now recognized as critical for proper compartmentalization
of insulin signaling. We previously demonstrated that, in adipocytes in a state of TNFα-induced
insulin resistance, the inhibition of insulin metabolic signaling and the elimination of ... Cited by 34 - Related articles - BL Direct - All 6 versions
- ►endojournals.org WL Holland, SA Summers - Endocrine Reviews, 2008 - Endocrine Soc Obesity and dyslipidemia are risk factors for metabolic disorders including diabetes and cardiovascular
disease. Sphingolipids such as ceramide and glucosylceramides, while being a relatively minor
component of the lipid milieu in most tissues, may be among the most pathogenic lipids in ... Cited by 30 - Related articles - All 7 versions
EW Kraegen, GJ Cooney - Current Opinion in Lipidology, 2008 - journals.lww.com Introduction The hypothesis that insulin resistance is related to tri- glyceride accumulation in
muscle and liver dates back to studies of 15–20 years ago showing that triglyceride accumulates
in muscle of high fat-fed rats, coincident with insulin resistance [1,2]. Since then the ... Cited by 25 - Related articles - BL Direct - All 2 versions
- ►uva.nl [PDF] K Ghauharali-van der Vlugt, M Langeveld, A Poppema, … - Clinica Chimica Acta, 2007 - Elsevier The ceramide concentration in plasma of untreated Gaucher patients was slightly but not significantly
lower than in controls (median: 9.8 µmol/L, range: 5.7–14.7 µmol/L, (n = 40) vs. median: 11.0
µmol/L, range: 5.1–18.0 µmol/L, (n = 30)). Glucosylceramide was significantly (p < ... Cited by 13 - Related articles - All 3 versions
L Yetukuri, K Ekroos, A Vidal-Puig, M Orešič - Molecular BioSystems, 2008 - rsc.org Recent advances in mass spectrometry (MS)-based techniques for lipidomic analysis have empowered
us with the tools that afford studies of lipidomes at the systems level. However, these techniques
pose a number of challenges for lipidomic raw data processing, lipid informatics, and the ... Cited by 13 - Related articles - Cached - BL Direct - All 4 versions
- ►endojournals.org MR Soeters, HP Sauerwein, JE Groener, JM … - Journal of Clinical …, 2007 - Endocrine Soc Results: Plasma glucose levels were significantly lower in women than men with a trend for a
lower endogenous glucose production in women, whereas FFA and lipolysis were significantly
higher. Insulin-mediated peripheral glucose uptake was not different between sexes. ... Cited by 11 - Related articles - BL Direct - All 4 versions
C Shah, G Yang, I Lee, J Bielawski, YA Hannun, F … - Journal of Biological …, 2008 - ASBMB Obesity increases the risk for metabolic and cardiovascular disease, and adipose tissue plays
a central role in this process. Ceramide, the key intermediate of sphingolipid metabolism, also
contributes to obesity-related disorders. We show that a high fat diet increased ceramide ... Cited by 9 - Related articles - All 4 versions
- ►endojournals.org M Langeveld, KJM Ghauharali, HP Sauerwein, … - Journal of Clinical …, 2008 - Endocrine Soc Context: Complex glycosphingolipids, in majority the ganglioside GM3, surround the insulin receptor
in a special membrane compartment (raft) and modulate signaling through this receptor. Increased
levels of GM3 in rafts impair insulin signaling, resulting in insulin resistance. Gaucher ... Cited by 8 - Related articles - All 5 versions
