- ►cell.com D Kabelitz, EK Geissler, B Soria, IS Schroeder … - Trends in Immunology, 2008 - Elsevier Type 1 diabetes (T1D) is an autoimmune disease that results from the destruction
of insulin-producing pancreatic islet cells owing to the aggressive effector
function of autoreactive T cells. In addition to lifetime supply of ... Cited by 10 - Related articles - All 4 versions
- ►nih.gov KS Goudy, B Wang, R Tisch - Clinical Immunology, 2008 - Elsevier Type 1 diabetes (T1D) is characterized by the T cell mediated destruction of the
insulin-producing β cells. Antigen-specific immunotherapies are used to
selectively tolerize β cell-specific pathogenic T cells either directly, ... Cited by 3 - Related articles - All 4 versions
L Li, Z Yi, R Tisch, B Wang - Archivum Immunologiae et Therapiae Experimentalis, 2008 - Springer Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing β
cells are destroyed. Diabetic patients man- age their hyperglycemia by daily
insulin injections. However, insulin therapy is by no means a cure. ... Cited by 3 - Related articles - All 4 versions
- ►j-talk.com MA Wallet, RR Flores, Y Wang, Z Yi, CJ … - Proceedings of the National Academy of Sciences, 2009 - National Acad Sciences T cell-mediated autoimmune diseases such as type 1 diabetes (T1D) are believed
to be the result in part of inefficient negative selection of self-specific
thymocytes. However, the events regulating thymic negative selection are ... Cited by 1 - Related articles - All 9 versions
Z Wang, C Zhao, R Moya, JD Davies - The Journal of Immunology, 2008 - Am Assoc Immnol Cachexia is the dramatic weight loss and muscle atrophy seen in chronic disease
states, including autoimmunity, cancer, and infection, and is often associated
with lymphopenia. We have previously shown that CD4 + T cells that express ... Cited by 2 - Related articles - All 4 versions
FS Wong, CM Dayan - Trends in Endocrinology & Metabolism, 2008 - Elsevier Regulatory T cells (Tregs) play a vital role in maintaining homeostatic balance
within the immune system. Tregs are required for mediating normal immune
responses against pathogens and then terminating such responses when no ... Cited by 1 - Related articles - All 6 versions
C Zhao, Z Wang, MW Robertson, JD Davies - Immunology, 2008 - pubmedcentral.nih.gov One of the long-term consequences of Type I diabetes is weight loss with muscle
atrophy, the hallmark phenotype of cachexia. A number of disorders that result
in cachexia are associated with immune deficiency. However, whether immune ... Cited by 1 - Related articles - All 5 versions
B Wang, R Tisch - Immunologic research, 2008 - Springer Abstract Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease in which
the insulin producing b cells are destroyed. Antigen-based immunotherapy
provides an approach to selectively tolerize pathogenic b cell-specific T ... Cited by 1 - Related articles - All 4 versions
- ►bayhilltx.com [PDF] N Solvason, YP Lou, W Peters, E Evans, J … - The Journal of Immunology, 2008 - Am Assoc Immnol Insulin is a major target for the autoimmune-mediated destruction of pancreatic
β cells during the pathogenesis of type I diabetes. A plasmid DNA vaccine
encoding mouse proinsulin II reduced the incidence of diabetes in a mouse ... Cited by 2 - Related articles - All 3 versions
ABTA Tolerance - medscape.com Antigen-based therapies (ABTs) seek to prevent or inhibit autoimmune diseases by
inducing regulatory T-cell responses (active tolerance) or anergizing/deleting
pathogenic T-cells (passive tolerance). The theoretical appeal of this ...
