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Scholar Results 1 - 10 of about 56 citing Vella: Effects of dipeptidyl peptidase-4 inhibition on gastrointestinal function, meal appearance.... (0.09 sec) 

Effects of vildagliptin on glucose control in patients with type 2 diabetes …


AJ Garber, JE Foley, MA Banerji, P Ebeling, … - Diabetes Obes …, 2008 - interscience.wiley.com
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Cited by 37 - Related articles - All 4 versions

Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, …


J Rosenstock, JE Foley, M Rendell, M Landin- … - Diabetes Care, 2008 - Am Diabetes Assoc
RESEARCH DESIGN AND METHODS—A 12-week, double-blind, randomized, parallel-group
study comparing vildagliptin (50 mg qd) and placebo was conducted in 179 subjects with IGT
(2-h glucose 9.1 mmol/l, A1C 5.9%). Plasma levels of intact glucagon-like peptide 1 ...
Cited by 28 - Related articles - BL Direct - All 5 versions

DPP-4 inhibitors

- insulinjournal.com [PDF] 
B Ahrén - Best Practice & Research Clinical Endocrinology & …, 2007 - Elsevier
Inhibition of dipeptidyl peptidase 4 (DPP-4) is a novel treatment for type-2 diabetes. DPP-4 inhibition
prevents the inactivation of glucagon-like peptide 1 (GLP-1), which increases levels of active
GLP-1. This increases insulin secretion and reduces glucagon secretion, thereby ...
Cited by 26 - Related articles - All 19 versions

Measurements of islet function and glucose metabolism with the dipeptidyl …

- endojournals.org
K Azuma, Z Radikova, J Mancino, FGS Toledo, … - Journal of Clinical …, 2008 - Endocrine Soc
Objective: Pharmacological inhibition with the dipeptidyl peptidase 4 (DPP-4) inhibitor vildagliptin
prolongs the action of endogenously secreted incretin hormones leading to improved glycemic
control in patients with type 2 diabetes mellitus (T2DM). We undertook a double-blinded, ...
Cited by 24 - Related articles - BL Direct - All 4 versions

Incretin-based therapies in type 2 diabetes mellitus

- endojournals.org
CW Chia, JM Egan - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc
Evidence Synthesis: Exenatide and liraglutide are injection based. Three-year follow-up data
on exenatide showed a sustained weight loss and glycosylated hemoglobin (HbA 1c ) reduction
of 1%. Nausea and vomiting are common. Results from phase 3 studies are pending on ...
Cited by 24 - Related articles - All 5 versions

Separate impact of obesity and glucose tolerance on the incretin effect in normal …

- diabetesjournals.org
E Muscelli, A Mari, A Casolaro, S Camastra, G Seghieri … - Diabetes, 2008 - Am Diabetes Assoc
RESEARCH DESIGN AND METHODS—Isoglycemic oral (75 g) and intravenous glucose administration
was performed in 51 subjects (24 with normal glucose tolerance [NGT], 17 with impaired glucose
tolerance [IGT], and 10 with type 2 diabetes) with a wide range of BMI (20–61 kg/m 2 ). C- ...
Cited by 19 - Related articles - BL Direct - All 10 versions

Management of Type 2 Diabetes in Treatment-Naive Elderly Patients


RE Pratley, J Rosenstock, FX Pi-Sunyer, MA … - Diabetes Care, 2007 - Am Diabetes Assoc
RESULTS—Mean baseline A1C and fasting plasma glucose (FPG) were significantly lower in
older (70 years: 8.3 ± 0.1% and 9.6 ± 0.1 mmol/l, respectively) than in younger (50 years: 8.7
± 0.0% and 10.5 ± 0.1 mmol/l, respectively) patients. Despite this, the adjusted mean ...
Cited by 20 - Related articles - BL Direct - All 5 versions

Characterization of the influence of vildagliptin on model-assessed-cell function in …

- endojournals.org
A Mari, WA Scherbaum, PM Nilsson, G Lalanne, … - Journal of Clinical …, 2008 - Endocrine Soc
Design: A 52-wk double-blind, randomized, parallel-group study comparing vildagliptin (50 mg
every day) and placebo was conducted in 306 patients with mild hyperglycemia (glycosylated
hemoglobin of 6.2–7.5%). Plasma glucose and C-peptide levels were measured during ...
Cited by 19 - Related articles - BL Direct - All 4 versions

Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses …


R Christopher, P Covington, M Davenport, P Fleck, QA … - Clinical Therapeutics, 2008 - Elsevier
Results: Thirty-six subjects (66 per cohort) were enrolled and completed the study (29/36
[81% ] white; mean age, 26.6 years; mean weight, 76.00 kg)..Alogliptin was rapidly absorbed
(median T max , 1-2 hours) and eliminated slowly (mean t 1/2 , 12.4-21.4 hours), primarily ...
Cited by 17 - Related articles - All 2 versions

Differential Antidiabetic Efficacy of Incretin Agonists Versus DPP-4 Inhibition in …

- diabetesjournals.org
BJ Lamont, DJ Drucker - Diabetes, 2008 - Am Diabetes Assoc
RESULTS AND CONCLUSIONS— Mice treated with vehicle alone or DA-GIP exhibited progressive
weight gain, whereas treatment with Ex-4 or DPP-4i prevented weight gain. Although Ex-4 improved
oral glucose tolerance and insulin-to-glucose ratios after an intraperitoneal glucose ...
Cited by 17 - Related articles - BL Direct - All 5 versions


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