- ►endojournals.org V Poitout, RP Robertson - Endocrine reviews, 2008 - Endocrine Soc Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that
are proposed to play a role in all forms of type 2 diabetes. The underlying
concept is that once the primary pathogenesis of diabetes is established, ... Cited by 69 - Related articles - BL Direct - All 7 versions
B Lands - Progress in Lipid Research, 2008 - Elsevier Beliefs about credible hypotheses of dietary causes of disease still need
well-defined mediators to test for logical proof or disproof. We know that food
energy causes transient postprandial oxidative insults that may not be ... Cited by 16 - Related articles - All 3 versions
BJ Goodwin, WJ Zuercher, JL Collins - Current Topics in Medicinal Chemistry, 2008 - ingentaconnect.com Abstract: The Liver X Receptors LXR and LXR are ligand-activated transcription
factors that belong to the nuclear hormone receptor superfamily. Seminal studies
with genetic and chemical tools were instrumental in the elucidation of ... Cited by 9 - Related articles - BL Direct - All 2 versions
V Poitout, J Amyot, M Semache, B Zarrouki, D … - BBA-Molecular and Cell Biology of Lipids, 2009 - Elsevier The concept of glucolipotoxicity refers to the combined, deleterious effects of
elevated glucose, and fatty acid levels on pancreatic beta-cell function and
survival. Significant progress has been made in recent years towards a ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►endojournals.org H Lee… - Endocrinology, 2008 - Endocrine Soc Prostate cancer is the most commonly diagnosed and the second leading cause of
cancer death in men. The androgens-androgen receptor signaling plays an
important role in normal prostate development, as well as in prostatic ... Cited by 5 - Related articles - All 4 versions
CD Green, DB Jump, LK Olson - Endocrinology, 2009 - Endocrine Soc Increased basal and loss of glucose-stimulated insulin secretion (GSIS) are
hallmarks of β-cell dysfunction associated with type 2 diabetes. It has been
proposed that elevated glucose promotes insulin secretory defects by ... Cited by 3 - Related articles - All 3 versions
C Fiévet, B Staels - Biochemical Pharmacology, 2009 - Elsevier Liver X receptors (LXRs) are nuclear receptors that play a crucial role in
regulating the expression of genes involved in lipid metabolism. Ligand
activation of LXRs improves cholesterol homeostasis via multiple ... Cited by 3 - Related articles - All 3 versions
Y Hashimoto - Archiv der Pharmazie, 2008 - interscience.wiley.com Thalidomide is a teratogenic/hypnotic/sedative agent which elicits a wide range
of pharmaceutical/biological activities. The diversity of its biological
activities suggested that the drug might be useful as a multi-template for ... Cited by 2 - Related articles - All 3 versions
M Baranowski - JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2008 - jpp.krakow.pl Liver X receptors (LXRs) are ligand-activated transcription factors of the
nuclear receptor superfamily. There are two LXR isoforms termed and ß which
upon activation form heterodimers with retinoid X receptor and bind to LXR ... Cited by 1 - Related articles - Cached - All 5 versions
