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Scholar Results 1 - 10 of about 15 citing Lau: Implantation Site–Dependent Dysfunction of Transplanted Pancreatic Islets. (0.09 sec) 

Optimal implantation site for pancreatic islet transplantation


S Merani, C Toso, J Emamaullee, AMJ … - British Journal of …, 2008 - ingentaconnect.com
Background: Since the first report of successful pancreatic islet transplantation to reverse
hyperglycaemia in diabetic rodents, there has been great interest in determining the optimal site
for implantation. Although the ...
Cited by 7 - Related articles - All 4 versions

Resolving the conundrum of islet transplantation by linking metabolic dysregulation …

- endojournals.org
X Huang, DJ Moore, RJ Ketchum, CS Nunemaker, B … - Endocrine …, 2008 - Endocrine Soc
Although type 1 diabetes cannot be prevented or reversed, replacement of insulin production by
transplantation of the pancreas or pancreatic islets represents a definitive solution. At present,
transplantation can restore ...
Cited by 5 - Related articles - All 4 versions

Low revascularization of human islets when experimentally transplanted into the …


J Lau, PO Carlsson - Transplantation, 2009 - journals.lww.com
This study was supported by grants from the Juvenile Diabetes Research Foundation, the Swedish
Research Council (55X-15043), the EFSD/Novo Nordisk Research Program, the EFSD/JDRF/Novo Nordisk
Research Program 2006, the Swedish ...
Cited by 4 - Related articles - All 3 versions

The choice of anatomical site for islet transplantation


DJ van der Windt, GJ Echeverri, JNM Ijzermans, … - Cell …, 2008 - ingentaconnect.com
Islet transplantation into the portal vein is the current clinical practice. However, it has now
been recognized that this implantation site has several characteristics that can hamper islet
engraftment and survival, such as ...
Cited by 3 - Related articles - All 2 versions

Intrahepatic Glucose Flux as a Mechanism for Defective Intrahepatic Islet α-Cell …

- diabetesjournals.org
H Zhou, T Zhang, M Bogdani, E Oseid, S Parazzoli, MC … - Diabetes, 2008 - Am Diabetes Assoc
RESULTS— Glucagon (area under the curve) responses to hypoglycemia in the H group (8,839 ± 1,988
pg/ml per 90 min) were significantly less than in normal rats (40,777 ± 8,192; P < 0.01). Fasting
significantly decreased hepatic ...
Cited by 3 - Related articles - All 4 versions

Beneficial role of pancreatic microenvironment for angiogenesis in transplanted …


J Lau, C Kampf, G Mattsson, D Nyqvist, M … - Cell …, 2009 - ingentaconnect.com
Pancreatic islets implanted heterotopically (ie, into the kidney, spleen, or liver) become poorly
revascularized following transplantation. We hypothesized that islets implanted into the pancreas
would become better revascularized. ...
Cited by 2 - Related articles - All 2 versions

Increased CD4+ CD25+ Foxp3+ regulatory T cells in tolerance induced by portal …


F He, Z Chen, S Xu, M Cai, M Wu, H Li, X Chen - Surgery, 2009 - Elsevier
Irradiated C57BL/6 (B6) splenocytes were injected into BALB/c mice via the portal vein. Seven days
after injection, the proportions of CD4 + CD25 + Foxp3 + regulatory T (Treg) cells were determined
in the blood, liver, and spleen. ...
Cited by 1 - Related articles - All 2 versions

Vascular niche of pancreatic islets


J Olerud, A Johansson, PO Carlsson - Expert Review of …, 2009 - ingentaconnect.com
Since the different endocrine cell types have dis- tinct locations in the rodent pancreas, with
b-cells mainly located in the core region, the direction of intra-islet blood perfusion has been
proposed to have significant impact ...
Related articles - All 3 versions

T cell immunity to islets of Langerhans: relevance for immunotherapy and …

- leidenuniv.nl [PDF] 
VAL Huurman - 2009 - openaccess.leidenuniv.nl
DIABETES MELLITUS The research presented in this thesis focuses on therapeutic strategies for type 1
diabetes mellitus (T1D). Diabetes mellitus (DM) is a commonly diagnosed metabolic disease resulting
from a disruption in glucose and ...
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Oxygenation of islets and its role in transplantation


J Lau, J Henriksnäs, J Svensson, PO … - Current Opinion in …, 2009 - pdfs.journals.lww.com
Introduction Pancreatic islets are highly metabolically active cells, depending on oxygen
consumption and glucose oxidation for their formation of ATP and subsequent insulin secretion.
Increased needs for insulin ...
Related articles - All 4 versions


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