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Scholar Results 1 - 10 of about 26 citing Xu: Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia. (0.07 sec) 

Separate impact of obesity and glucose tolerance on the incretin effect in normal …

- diabetesjournals.org
E Muscelli, A Mari, A Casolaro, S Camastra, G Seghieri … - Diabetes, 2008 - Am Diabetes Assoc
RESEARCH DESIGN AND METHODS—Isoglycemic oral (75 g) and intravenous glucose administration was
performed in 51 subjects (24 with normal glucose tolerance [NGT], 17 with impaired glucose tolerance
[IGT], and 10 with type 2 diabetes) ...
Cited by 19 - Related articles - BL Direct - All 10 versions

Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing …


S Piteau, A Olver, SJ Kim, K Winter, JA Pospisilik, F … - … and Biophysical Research …, 2007 - Elsevier
In type 2 diabetes (T2DM) β-cell responsiveness to glucose-dependent insulinotropic polypeptide
(GIP) is reduced. In a model of T2DM, the VDF Zucker rat, GIP receptor mRNA and protein levels were
shown to be down-regulated. ...
Cited by 12 - Related articles - All 4 versions

Preservation of β-cell function by targeting β-cell mass

- cell.com
EJP de Koning, S Bonner-Weir, TJ Rabelink - Trends in Pharmacological …, 2008 - Elsevier
Type 2 diabetes is characterized by progressive β-cell dysfunction and a reduction in β-cell mass.
Pancreatic islets are a target for adverse effectors such as high concentrations of glucose,
pro-inflammatory cytokines and ...
Cited by 14 - Related articles - All 4 versions

Glucagon-like peptide-1, glucose homeostasis and diabetes


JJ Holst, CF Deacon, T Vilsbøll, T Krarup, S … - Trends in Molecular …, 2008 - Elsevier
Incretins, enhancers of insulin secretion, are essential for glucose tolerance, and a reduction in
their function might contribute to poor β-cell function in patients with type-2 diabetes mellitus.
However, at supraphysiological ...
Cited by 10 - Related articles - All 4 versions

Ileal transposition controls diabetes as well as modified duodenal jejunal bypass …


TT Wang, SY Hu, HD Gao, GY Zhang, CZ Liu, JB … - Annals of …, 2008 - journals.lww.com
Reprints: Eldo Ermenegildo Frezza, MD, MBA, FACS, Department of Surgery, Division of General
Surgery, Texas Tech University Health Sciences Center, 3601, 4th Street, MS 8312, Lubbock, Texas
79430. E-mail: ...
Cited by 9 - Related articles - BL Direct - All 3 versions

The role of incretins in glucose homeostasis and diabetes treatment

- nih.gov
W Kim, JM Egan - Pharmacological reviews, 2008 - ASPET
Cited by 12 - Related articles - All 5 versions

Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide …


HE Parker, AM Habib, GJ Rogers, FM Gribble, F … - Diabetologia, 2009 - Springer
Abstract Aims/hypothesis Glucose-dependent insulinotropic poly- peptide (GIP) is an incretin hormone
with anti-apoptotic effects on the pancreatic beta cell. The aim of this study was to generate
transgenic mice with fluorescently ...
Cited by 6 - Related articles - All 2 versions

Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in …

- physiology.org
J Zhou, MFA Livak, M Bernier, DC Muller, … - American Journal of …, 2007 - Am Physiological Soc
Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that has a potent
stimulatory effect on insulin release under conditions of normal glucose tolerance. However, its
insulinotropic effect is reduced or ...
Cited by 5 - Related articles - BL Direct - All 6 versions

Chronic glucagon-like peptide-1 infusion sustains left ventricular systolic function …

- ahajournals.org
I Poornima, SB Brown, S Bhashyam, P Parikh, … - Circulation: Heart …, 2008 - Am Heart Assoc
Methods and Results— At 9 months of age, 50 SHHF rats were randomized to receive a 3-month,
continuous infusion of either GLP-1 or saline. Metabolic parameters were measured and cardiac
ultrasounds performed at study ...
Cited by 5 - Related articles - All 4 versions

Combining a dipeptidyl peptidase-4 inhibitor, alogliptin, with pioglitazone improves …


Y Moritoh, K Takeuchi, T Asakawa, O … - British Journal of …, 2009 - interscience.wiley.com
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Cited by 3 - Related articles - All 2 versions


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