- ►ucsd.edu [PDF] CG Jolivalt, CA Lee, KM Ramos, NA Calcutt - Pain, 2008 - Elsevier Diabetic rats show behavioral indices of painful neuropathy that may model the human
condition. Hyperalgesia during the formalin test in diabetic rats is accompanied by the apparently
paradoxical decrease in spinal release of excitatory neurotransmitters and increase in the ... Cited by 8 - Related articles - All 17 versions
- ►cjb.net M Chattopadhyay, M Mata, DJ Fink - Journal of Neuroscience, 2008 - neuro.cjb.net The Na V 1.7 tetrodotoxin-sensitive voltage-gated sodium channel isoform plays a critical role
in nociception. In rodent models of diabetic neuropathy, increased Na V 1.7 in dorsal root ganglia
(DRG) neurons correlates with the emergence of pain-related behaviors characteristic of ... Cited by 7 - Related articles - All 4 versions
- ►wisc.edu [PDF] NA Calcutt, MM Backonja - Current Diabetes Reports, 2007 - Springer Recent advances in understanding the pain associated with diabetic neuropathy are likely to
provide significant mechanistic insights and offer better therapies. In clini- cal research, new
tools for measuring neuropathic pain and validation of histologic and other biomarkers ... Cited by 6 - Related articles - BL Direct - All 3 versions
DR Tomlinson, NJ Gardiner - Journal of the Peripheral Nervous …, 2008 - interscience.wiley.com Abstract This review examines the putative role of glucose in the etiology of diabetic
neuropathies. Excessive glucose generates several secondary metabolic anomalies — principally
oxidative stress (via both the polyol pathway and glucoxidation) and non-enzymic ... Cited by 3 - Related articles - All 3 versions
IG Obrosova - BBA-Molecular Basis of Disease, 2009 - Elsevier Diabetes-induced damage to peripheral nerve culminates in development of peripheral diabetic
neuropathy (PDN), one of the most devastating complications of diabetes mellitus and a leading
cause of foot amputation. The pathogenesis of PDN occurs as a consequence of complex ... Cited by 1 - Related articles - All 2 versions
D Vardeh, D Wang, M Costigan, M … - The Journal of …, 2009 - pubmedcentral.nih.gov A cardinal feature of peripheral inflammation is pain. The most common way of managing inflammatory
pain is to use nonsteroidal antiinflammatory agents (NSAIDs) that reduce prostanoid
production, for example, selective inhibitors of COX2. Prostaglandins produced after ... Cited by 1 - Related articles - All 7 versions
JM Cunha, CG Jolivalt, KM Ramos, JA … - Metabolism: clinical …, 2008 - pubmedcentral.nih.gov We investigated the effect of treatment with an aldose reductase inhibitor, insulin or select neurotrophic
factors on the generation of oxidative damage in peripheral nerve. Rats were either treated with
streptozotocin (STZ) to induce insulin-deficient diabetes or fed with a diet containing 40% ... Cited by 2 - Related articles - All 22 versions
- ►nih.gov DH Kim, B Fitzsimmons, MP Hefferan, CI Svensson, E … - Neuroscience, 2008 - Elsevier Activation of the spinal phospholipase A 2 (PLA 2 ) –cyclooxygenase (COX) –prostaglandin signaling
pathway is widely implicated in nociceptive processing. Although the role of spinal COX isoforms
in pain signal transmission has been extensively characterized, our knowledge of PLA 2 ... Cited by 2 - Related articles - All 4 versions
R Pop-Busui, AP Kellogg, HT Cheng - Current Drug Targets, 2008 - ingentaconnect.com Abstract: Diabetic peripheral neuropathy (DPN) is the most common diabetic complication and
is the leading cause of diabetes-related hospital admissions and non-traumatic amputations.
DPN is also associated with a poor quality of life and high economic costs for both type 1 ... Related articles
IG Obrosova - Neurotherapeutics, 2009 - Elsevier Advanced peripheral diabetic neuropathy (PDN) is associated with elevated vibration and thermal
perception thresholds that progress to sensory loss and degeneration of all fiber types in peripheral
nerve. A considerable proportion of diabetic patients also describe abnormal sensations ... Related articles - All 23 versions
