J Backer - Biochem. J, 2008 - biochemj.org The Class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first
described as a component of the vacuolar sorting system in Saccharomyces cerevisiae and is
the sole PI3K in yeast. The homologue in mammalian cells, hVps34, has been studied ... Cited by 52 - Related articles - Cached - BL Direct - All 6 versions
S Schenk, M Saberi, JM Olefsky - The Journal of Clinical …, 2008 - pubmedcentral.nih.gov Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of
a number of diseases, including type 2 diabetes. In this review, we discuss potential mechanisms
by which brief nutrient excess and obesity lead to insulin resistance and propose that ... Cited by 47 - Related articles - All 12 versions
- ►diabetesjournals.org M Fraenkel, M Ketzinel-Gilad, Y Ariav, O Pappo, M … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Unexpectedly, rapamycin worsened hyperglycemia in diabetic P. obesus without
affecting glycemia in normoglycemic controls. There was a 10-fold increase of serum insulin
in diabetic P. obesus compared with controls; rapamycin completely abolished this ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►physiology.org PL Greenhaff, LG Karagounis, N Peirce, … - American Journal of …, 2008 - Am Physiological Soc We determined the effects of intravenous infusion of amino acids (AA) at serum insulin of 5,
30, 72, and 167 mU/l on anabolic signaling, expression of ubiquitin-proteasome
components, and protein turnover in muscles of healthy young men. Tripling AA ... Cited by 23 - Related articles - All 6 versions
- ►cell.com P Polak, N Cybulski, JN Feige, J Auwerx, MA Rüegg, … - Cell metabolism, 2008 - Elsevier The protein kinase target of rapamycin (TOR) is a highly conserved, central controller of cell growth
and metabolism ([Corradetti and Guan, 2006], [Guertin and Sabatini, 2007] and [Wullschleger
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- ►amjpathol.org X Jiang, H Kenerson, L Aicher, R Miyaoka, J Eary, J … - American Journal of …, 2008 - ASIP Human cancers often display an avidity for glucose, a feature that is exploited in clinical staging
and response monitoring by using 18 F-fluoro-deoxyglucose (FDG) positron emission
tomography. Determinants of FDG accumulation include tumor blood flow, glucose ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►animal-science.org X Yang, C Yang, A Farberman, TC Rideout, … - Journal of Animal …, 2008 - animal-science.org The mammalian target of rapamycin (mTOR) plays key roles in cellular metabolism and
hypertrophic-hyperplasic growth, and it acts as a central regulator of protein synthesis and ribosome
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A Donati, G Recchia, G Cavallini, E … - Journals of Gerontology …, 2008 - Geron Soc America Autophagy is a process that sequesters and degrades altered organelles and macromolecular
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MJ Drummond, CS Fry, EL Glynn, HC Dreyer … - The Journal of …, 2009 - Physiological Soc Muscle protein synthesis and mTORC1 signalling are concurrently stimulated following muscle
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S Boura-Halfon, Y Zick - American Journal of Physiology- …, 2009 - Am Physiological Soc Insulin signaling at target tissues is essential for growth and development and for normal homeostasis
of glucose, fat, and protein metabolism. Control over this process is therefore tightly
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