M Coghlan, B Leighton - Expert Opin. Investig. Drugs, 2008 - informahealthcare.com Type 2 diabetes is a chronic metabolic disease that adversely affects both the
quality and longevity of life. The disease is characterised by elevated blood
glucose (hyperglycaemia) that is associated with microvascular ... Cited by 12 - Related articles - BL Direct - All 6 versions
M Combettes, C Kargar - Therapie, 2007 - edpsciences. org Abstract – Type 2 diabetes is an endocrine/metabolic disease characterized by
hyperglycemia. It is now well established that insulin resistance and pancreatic
β-cell dysfunction/failure are the two major components of the ... Cited by 10 - Related articles - All 3 versions
R Sarabu, SJ Berthel, RF Kester, JW Tilley - Expert Opin. Ther. Patents, 2008 - informahealthcare.com Background: Small molecule glucokinase activators (GKAs) represent a new
strategy to treat type 2 diabetes. Glucokinase (GK) primarily exerts its effect
through modulatory actions in the pancreatic β-cells and the liver. It ... Cited by 10 - Related articles - All 4 versions
- ►eje.org HBT Christesen, ND Tribble, A Molven, J … - European Journal of Endocrinology, 2008 - eje.org Results: In five patients, four heterozygous GCK mutations (S64Y, T65I, W99R and
A456V) were identified, out of which S64Y was novel. Two of the mutations arose
de novo, three were dominantly inherited. All the five patients were ... Cited by 7 - Related articles - All 7 versions
D Johnson, RM Shepherd, D Gill, T Gorman, … - Biochemical Society Transactions, 2007 - biochemsoctrans.org 1208 Biochemical Society Transactions (2007) Volume 35, part 5 ... D. Johnson*,
RM Shepherd*, D. Gill†, T. Gorman†, DM Smith† and MJ Dunne*1 *Faculty of
Life Sciences, University of Manchester, Core Technology Facility, 46 ... Cited by 4 - Related articles - View as HTML - BL Direct - All 3 versions
HBT Christesen, K Brusgaard, H Beck Nielsen … - CLINICAL ENDOCRINOLOGY-OXFORD-, 2008 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 3 - Related articles - BL Direct - All 6 versions
A Nakamura, Y Terauchi, S Ohyama, J Kubota, … - Endocrinology, 2009 - Endocrine Soc We investigated the effect of glucokinase activator (GKA) on glucose metabolism
and β-cell mass. We analyzed four mouse groups: wild-type mice and
β-cell-specific haploinsufficiency of glucokinase gene (Gck +/– ) mice ... Cited by 4 - Related articles - All 3 versions
R Sarabu, R Taub, J Grimsby - Drug Discovery Today: Therapeutic Strategies, 2007 - Elsevier Type 2 diabetes (T2D) is a progressive disease that affects over 150 million
patients worldwide. It is characterized by chronic persistent hyperglycemia and
dyslipidemia, which left untreated, leads to diabetic nephropathies and ... Cited by 2 - Related articles
P Wei, M Shi, S Barnum, H Cho, T Carlson, JD … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Glucokinase (GK), an enzyme that phos- phorylates
glucose to form glucose 6-phosphate, serves as the glucose sensor that regulates
insulin secretion in beta cells. GK activators (GKAs) activate GK via ... Related articles - All 2 versions
