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Scholar Results 1 - 10 of about 149 citing Cani: Metabolic endotoxemia initiates obesity and insulin resistance. (0.12 sec) 

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation …

- diabetesjournals.org
PD Cani, R Bibiloni, C Knauf, A Waget, AM Neyrinck, … - Diabetes, 2008 - Am Diabetes Assoc
RESULTS—We found that changes of gut microbiota induced by an antibiotic treatment reduced
metabolic endotoxemia and the cecal content of LPS in both high-fat–fed and ob/ob mice. This
effect was correlated with reduced glucose intolerance, body weight gain, fat mass ...
Cited by 60 - Related articles - All 5 versions

Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced …

- ucl.ac.be [PDF] 
PD Cani, AM Neyrinck, F Fava, C Knauf, RG Burcelin, … - Diabetologia, 2007 - Springer
Abstract Aims/hypothesis Recent evidence suggests that a particular gut microbial community
may favour occurrence of the metabolic diseases. Recently, we reported that high-fat (HF) feeding
was associated with higher endotoxaemia and lower Bifidobacterium species (spp.) ...
Cited by 62 - Related articles - BL Direct - All 3 versions

Insulin sensitivity: modulation by nutrients and inflammation


S Schenk, M Saberi, JM Olefsky - The Journal of Clinical …, 2008 - pubmedcentral.nih.gov
Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of
a number of diseases, including type 2 diabetes. In this review, we discuss potential mechanisms
by which brief nutrient excess and obesity lead to insulin resistance and propose that ...
Cited by 47 - Related articles - All 12 versions

Remodeling phenotype of human subcutaneous adipose tissue macrophages

- ahajournals.org
V Bourlier, A Zakaroff-Girard, A Miranville, S De Barros, … - Circulation, 2008 - Am Heart Assoc
Methods and Results— The present study, performed on human subcutaneous AT, showed that
ATMs from lean to overweight individuals are composed of distinct macrophage subsets based
on the expression of several cell surface markers: CD45, CD14, CD31, CD44, HLA-DR, ...
Cited by 41 - Related articles - All 6 versions

Adipose tissue macrophages, low grade inflammation and insulin resistance in …


LK Heilbronn, LV Campbell - Current Pharmaceutical Design, 2008 - ingentaconnect.com
Abstract: Obesity was first described as a low-grade inflammatory condition more than a decade
ago. However, it is only relatively re- cently that obese individuals have been described with
increased macrophage infiltration of adipose tissue, as well as an increase in the number ...
Cited by 36 - Related articles - BL Direct - All 2 versions

Toll-like receptors and adaptor molecules in liver disease: update


E Seki, DA Brenner - Hepatology, 2008 - interscience.wiley.com
Toll-like receptors (TLRs) are pattern recognition receptors that recognize pathogen-associated
molecular patterns and signal through adaptor molecules, myeloid differentiation factor 88
(MyD88), Toll/IL-1 receptor domain containing adaptor protein (TIRAP), Toll/IL-1 receptor ...
Cited by 33 - Related articles - All 2 versions

Gut microbiota and its possible relationship with obesity

- mayoclinicproceedings.com
JK DiBaise, H Zhang, MD Crowell, R … - Mayo Clinic …, 2008 - mayoclinproc.highwire.org
Obesity results from alterations in the body's regulation of energy intake, expenditure, and
storage. Recent evidence, primarily from investigations in animal models, suggests that the gut
microbiota affects nutrient acquisition and energy regulation. Its composition has also ...
Cited by 31 - Related articles - BL Direct - All 8 versions

Gut microbiota modulation with norfloxacin and ampicillin enhances glucose …

- fasebj.org
M Membrez, F Blancher, M Jaquet, R Bibiloni, PD Cani, … - The FASEB Journal, 2008 - FASEB
Recent data suggest that the gut microbiota plays a significant role in fat accumulation.
However, it is not clear whether gut microbiota is involved in the pathophysiology of type 2
diabetes. To assess this issue, we modulated gut microbiota via antibiotics administration ...
Cited by 29 - Related articles - All 6 versions

Metabolic effects of dietary fiber consumption and prevention of diabetes

- nutrition.org
MO Weickert, AFH Pfeiffer - Journal of Nutrition, 2008 - Am Soc Nutrition
A high dietary fiber (DF) intake is emphasized in the recommendations of most diabetes and
nutritional associations. It is accepted that viscous and gel-forming properties of soluble DF inhibit
macronutrient absorption, reduce postprandial glucose response, and beneficially ...
Cited by 30 - Related articles - All 3 versions

A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism …


C Erridge, T Attina, CM Spickett, DJ … - American Journal of …, 2007 - Am Soc Nutrition
2 Supported by British Heart Foundation Junior Fellowship (FS/03/97; to CE) and by a grant from
the Scottish Executive Chief Scientist Office (CZG/1/121). Strain NCTC 13114 was donated by
Ian Poxton, University of Edinburgh. ... Background: Bacterial endotoxin is a potently ...
Cited by 28 - Related articles - BL Direct - All 6 versions


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