- ►endojournals.org V Poitout, RP Robertson - Endocrine reviews, 2008 - Endocrine Soc Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that
are proposed to play a role in all forms of type 2 diabetes. The underlying
concept is that once the primary pathogenesis of diabetes is established, ... Cited by 71 - Related articles - BL Direct - All 7 versions
- ►physoc.org P Newsholme, EP Haber, SM Hirabara, ELO … - The Journal of Physiology, 2007 - Physiological Soc It is now widely accepted, given the current weight of experimental evidence,
that reactive oxygen species (ROS) contribute to cell and tissue dysfunction and
damage caused by glucolipotoxicity in diabetes. The source of ROS in the ... Cited by 62 - Related articles - BL Direct - All 8 versions
C Guay, SR Madiraju, A Aumais, E Joly, M … - Journal of Biological Chemistry, 2007 - ASBMB In pancreatic β-cells, metabolic coupling factors generated during glucose
metabolism and pyruvate cycling through anaplerosis/cataplerosis processes
contribute to the regulation of insulin secretion. Pyruvate/citrate cycling ... Cited by 25 - Related articles - All 4 versions
- ►diabetesjournals.org AI Oprescu, G Bikopoulos, A Naassan, EM … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—Forty-eight–hour infusion of oleate decreased the insulin and
C-peptide responses to a hyperglycemic clamp (P < 0.01), an effect prevented by
coinfusion of the antioxidants N-acetylcysteine (NAC) and taurine. Similar ... Cited by 21 - Related articles - BL Direct - All 3 versions
S Lenzen - Biochemical Society Transactions, 2008 - biochemsoctrans.org Antioxidative defence mechanisms of pancreatic β-cells are particularly weak
and can be overwhelmed by redox imbalance arising from overproduction of
reactive oxygen and reactive nitrogen species. The consequences of this ... Cited by 16 - Related articles - Cached - BL Direct - All 6 versions
- ►cell.com CJ Nolan, M Prentki - Trends in Endocrinology & Metabolism, 2008 - Elsevier The pancreatic β-cell senses blood nutrient levels and is modulated by
neurohormonal signals so that it secretes insulin according to the need of the
organism. Nutrient sensing involves marked metabolic activation, resulting ... Cited by 7 - Related articles - All 8 versions
J Pi, Y Bai, KW Daniel, D Liu, O Lyght, D … - Endocrinology, 2009 - Endocrine Soc Uncoupling protein (UCP) 2 is a widely expressed mitochondrial protein whose
precise function is still unclear but has been linked to mitochondria-derived
reactive oxygen species production. Thus, the chronic absence of UCP2 has ... Cited by 8 - Related articles - All 3 versions
- ►diabetesjournals.org C Leloup, C Tourrel-Cuzin, C Magnan, M Karaca … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Transient glucose increase from 5.5 to 16.7 mmol/l stimulated ROS
generation, which was reversed by antioxidants. Insulin secretion was dose
dependently blunted by antioxidants and highly correlated with ROS levels. ... Cited by 7 - Related articles - All 4 versions
XD Wang, MZ Vatamaniuk, SK Wang, CA … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis We previously observed hyperglycaemia,
hyperinsulinaemia, insulin resistance and obesity in Gpx1- overexpressing mice
(OE). Here we determined whether these phenotypes were eliminated by diet ... Cited by 6 - Related articles - All 3 versions
N Li, F Frigerio, P Maechler - Biochemical Society Transactions, 2008 - biochemsoctrans.org Pancreatic β-cells are essential for the maintenance of glucose homoeostasis,
and dysfunction of these insulin-secreting cells results in the development of
diabetes. In the course of events leading from obesity to Type 2 diabetes, ... Cited by 3 - Related articles - Cached - All 4 versions
