PC Butler, JJ Meier, AE Butler, A Bhushan - Nature clinical practice. …, 2007 - ncbi.nlm.nih.gov Replication of beta cells is an important source of beta-cell expansion in early childhood. The
recent linkage of type 2 diabetes with several transcription factors involved in cell cycle regulation
implies that growth of the beta-cell mass in early childhood might be an important ... Cited by 42 - Related articles - BL Direct - All 3 versions
JJ Meier, AE Butler, Y Saisho, T Monchamp, R Galasso … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Little is known about the capacity, mechanisms, or timing of growth in β-cell mass
in humans. We sought to establish if the predominant expansion of β-cell mass in humans occurs
in early childhood and if, as in rodents, this coincides with relatively abundant β-cell ... Cited by 23 - Related articles - All 3 versions
M Zhao, SA Amiel, S Ajami, J Jiang, M Rela, N … - PLoS ONE, 2008 - pubmedcentral.nih.gov Two hMSC lines were transfected with three genes: PDX-1, NeuroD1 and Ngn3 without subsequent
selection, followed by differentiation induction in vitro and transplantation into diabetic mice.
Human MSCs expressed mRNAs of the archetypal stem cell markers: Sox2, Oct4, Nanog ... Cited by 5 - Related articles - All 5 versions
V Sordi, F Bertuzzi, L Piemonti - Regen. Med., 2008 - Future Medicine In both Type 1 and 2 diabetes, insufficient numbers of insulin-producing β-cells are a major cause
of defective control of blood glucose and its complications. Restoration of damaged β-cells by
endocrine pancreas regeneration would be an ideal therapeutic option. The possibility of ... Cited by 5 - Related articles - BL Direct - All 4 versions
CEB Couri, JC Voltarelli - Arquivos Brasileiros de Endocrinologia & …, 2008 - SciELO Brasil Type 1 diabetes mellitus is the result of the autoimmune response against pancreatic
b-cell(s). At the time of clinical diagnosis near 70% of b-cell mass is been destroyed as a consequence
of the auto-destruction that begins months or even years before the clinical diagnosis. ... Cited by 5 - Related articles - Cached - All 4 versions
B Couri, C Eduardo, MC Foss-Freitas, MC … - Expert Review of …, 2008 - ingentaconnect.com Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of the insulin- producing
pancreatic β-cells. The autoimmune response begins years before the presentation of hyperglycemic
symptoms. At the time of clinical diagnosis, less than 30% of β-cell mass still remains. The ... Cited by 5 - Related articles - BL Direct - All 3 versions
- ►ufl.edu [PDF] MA Atkinson, R Gianani - Current Opinion in Endocrinology, Diabetes …, 2009 - journals.lww.com Recent findings: As historically noted, a pancreatic infiltrate commonly referred to as
'insulitis' is present at the symptomatic onset of T1D. Recent studies have further characterized
this infiltrate both in terms of its cellular composition as well as the mechanisms that likely ... Cited by 1 - Related articles - All 3 versions
J Agudo, E Ayuso, V Jimenez, A Salavert, A Casellas, S … - Diabetologia, 2008 - Springer Page 1. ARTICLE IGF-I mediates regeneration of endocrine pancreas by increasing beta cell
replication through cell cycle protein modulation in mice J. Agudo & E. Ayuso & V. Jimenez
& A. Salavert & A. Casellas & S. Tafuro & V. Haurigot & J. Ruberte & ... Cited by 1 - Related articles - All 2 versions
M Campbell-Thompson, LR Dixon, C Wasserfall, M … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Recent histological analysis of pancreases obtained from patients
with long-standing type 1 diabetes identified chronic islet inflammation and limited evidence
suggestive of beta cell replication. Studies in rodent models also suggest that beta cell ... Cited by 1 - Related articles - All 3 versions
JCJ Pérez, I Garza Veloz, R Ortiz López - Medicina Universitaria, 2007 - medigraphic.com Las células madre tienen la capacidad de autorenovarse y diferenciarse para producir diversos
tipos de células especializadas. Las células madre se clasifican por su potencial de diferenciación
en totipotenciales, pluripotenciales y multipotenciales, y según el tejido de origen en ... Cited by 1 - Related articles - All 6 versions
