JA Hawley, SJ Lessard - Acta Physiologica, 2008 - interscience.wiley.com Individuals with insulin resistance are characterized by impaired insulin action on whole-body
glucose uptake, in part due to impaired insulin-stimulated glucose uptake into skeletal
muscle. A single bout of exercise increases skeletal muscle glucose uptake via an insulin- ... Cited by 36 - Related articles - BL Direct - All 3 versions
- ►endojournals.org WL Holland, SA Summers - Endocrine Reviews, 2008 - Endocrine Soc Obesity and dyslipidemia are risk factors for metabolic disorders including diabetes and cardiovascular
disease. Sphingolipids such as ceramide and glucosylceramides, while being a relatively minor
component of the lipid milieu in most tissues, may be among the most pathogenic lipids in ... Cited by 30 - Related articles - All 7 versions
- ►physiology.org C Moro, S Bajpeyi, SR Smith - American Journal of Physiology- …, 2008 - Am Physiological Soc Increased intramyocellular triglyceride (IMTG) content is found in both insulin-sensitive
endurance-trained subjects and insulin-resistant obese/type 2 diabetic subjects. A high turnover
rate of the IMTG pool in athletes is proposed to reduce accumulation of lipotoxic ... Cited by 23 - Related articles - BL Direct - All 6 versions
- ►physiology.org AS Mathai, A Bonen, CR Benton, DL … - Journal of Applied …, 2008 - Am Physiological Soc The mRNA of the nuclear coactivator peroxisome proliferator-activated receptor-
coactivator-1 (PGC-1 ) increases during prolonged exercise and is influenced by carbohydrate
availability. It is unknown if the increases in mRNA reflect the PGC-1 protein or if glycogen ... Cited by 18 - Related articles - All 3 versions
CR Benton, GP Holloway, SE Campbell, Y … - The Journal of …, 2008 - Physiological Soc Peroxisome proliferator-activated receptors (PPARs) alter the expression of genes involved in
regulating lipid metabolism. Rosiglitazone, a PPARγ agonist, induces tissue-specific effects on
lipid metabolism; however, its mode of action in skeletal muscle remains unclear. Since ... Cited by 10 - Related articles - BL Direct - All 6 versions
T Kanda, JD Brown, G Orasanu, S Vogel, … - The Journal of …, 2009 - pubmedcentral.nih.gov Although endothelial dysfunction, defined as abnormal vasoreactivity, is a common early finding
in individuals with type 2 diabetes, the endothelium has not been known to regulate
metabolism. As PPARγ, a transcriptional regulator of energy balance, is expressed in ... Cited by 6 - Related articles - All 7 versions
- ►physiology.org BB Yaspelkis III, SJ Lessard, DW Reeder, … - American Journal of …, 2007 - Am Physiological Soc The aims of this investigation were 1) to determine whether endurance exercise training could
reverse impairments in insulin-stimulated compartmentalization and/or activation of aPKC / and
Akt2 in skeletal muscle from high-fat-fed rodents and 2) to assess whether the PPAR ... Cited by 5 - Related articles - BL Direct - All 3 versions
- ►physiology.org I Pagel-Langenickel, DR Schwartz, RA … - American Journal of …, 2007 - Am Physiological Soc Skeletal muscle mitochondrial dysfunction is hypothesized to contribute to the pathophysiology
of insulin resistance and Type 2 diabetes. Whether thiazolidinedione therapy enhances skeletal
muscle mitochondrial function as a component of its insulin-sensitizing effect is unknown. ... Cited by 4 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org P Dallaire, K Bellmann, M Laplante, S Gélinas, C … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Rosiglitazone was found to similarly improve whole-body insulin sensitivity and
insulin signaling to Akt/PKB in skeletal muscle of obese iNOS –/– and obese iNOS +/+ mice.
However, rosiglitazone further improved glucose tolerance and liver insulin signaling only ... Cited by 3 - Related articles - All 4 versions
- ►endojournals.org AW Norris, MF Hirshman, J Yao, N Jessen, N Musi, L … - Endocrinology, 2008 - Endocrine Soc In the setting of insulin resistance, agonists of peroxisome proliferator-activated receptor
(PPAR)- restore insulin action in muscle and promote lipid redistribution. Mice with muscle-specific
knockout of PPAR (MuPPAR KO) develop excess adiposity, despite reduced food intake ... Cited by 2 - Related articles - All 3 versions
