- ►endojournals.org V Poitout, RP Robertson - Endocrine reviews, 2008 - Endocrine Soc Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that
are proposed to play a role in all forms of type 2 diabetes. The underlying
concept is that once the primary pathogenesis of diabetes is established, ... Cited by 71 - Related articles - BL Direct - All 7 versions
V Poitout, J Amyot, M Semache, B Zarrouki, D … - BBA-Molecular and Cell Biology of Lipids, 2009 - Elsevier The concept of glucolipotoxicity refers to the combined, deleterious effects of
elevated glucose, and fatty acid levels on pancreatic beta-cell function and
survival. Significant progress has been made in recent years towards a ... Cited by 9 - Related articles - BL Direct - All 4 versions
SE Choi, YJ Lee, HJ Jang, KW Lee, YS Kim, … - Archives of biochemistry and biophysics, 2008 - Elsevier Free fatty acids (FFAs) are believed to be a stimulus to elicit beta cell
dysfunction. The present study was undertaken to determine whether endoplasmic
reticulum (ER) stress was involved in palmitate-induced inhibition of ... Cited by 5 - Related articles - All 4 versions
CA Girard, FT Wunderlich, K Shimomura, S … - The Journal of Clinical Investigation, 2009 - pubmedcentral.nih.gov Neonatal diabetes is a rare monogenic form of diabetes that usually presents
within the first six months of life. It is commonly caused by gain-of-function
mutations in the genes encoding the Kir6.2 and SUR1 subunits of the ... Cited by 3 - Related articles - All 10 versions
- ►nih.gov SC Collins, A Salehi, L Eliasson, CS … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Long-term exposure to NEFAs leads to inhibition of
glucose-induced insulin secretion. We tested whether the release of somatostatin
and glucagon, the two other major islet hormones, is also affected. Methods ... Cited by 2 - Related articles - All 6 versions
E Renström, P Rorsman - Pancreatic Beta Cell in Health and Disease, 2007 - Springer Summary. Insulin is stored in secretory granules within the pancreatic beta
cell. The release of insulin requires the fusion of the secretory granule with
the plasma membrane and the discharge of the granule contents into the ... Related articles - All 2 versions
- ►duke.edu [PDF] CT Ferrara - dukespace.lib.duke.edu Page 1. Metabolic Pathways of Type 2 Diabetes Intersection of Genetics,
Transcriptomics, and Metabolite Profiling by Christine Therese Ferrara ... Related articles - View as HTML - All 3 versions
C Soekmadji, P Thorn - Proceedings of the Australian Physiological Society, 2009 - apps.org.au 2. In the classical model of secretion each fused vesicle releases the entirety
of its content in an all-or-none manner. In this way the secretory output of a
cell is controlled by regulating the numbers of fused vesicles. The ... Related articles - Cached - All 3 versions
周晓磊， 陈玉涛， 薛承锐 - 中国老年保健医学, 2009 - journal.shouxi.net 【Abstract】 Objective To observe the proteic expression of pancreatic KATP
channels SUR1 in diabetes rats，and the Intervention of nateglinide and
Danshensu on the changes. Methods Wistar rats were fed high glucose/fat ... Related articles - Cached - All 3 versions