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Scholar Results 1 - 10 of about 38 citing Knop: Reduced Incretin Effect in Type 2 Diabetes. (0.11 sec) 

Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose …

- diabetesjournals.org
K Vollmer, JJ Holst, B Baller, M Ellrichmann, … - Diabetes, 2008 - Am Diabetes Assoc
RESULTS—GIP and GLP-1 levels increased significantly in both experiments (P <
0.0001). In patients with type 2 diabetes, the initial GIP response was
exaggerated compared with control subjects after mixed meal (P < 0.001) but ...
Cited by 31 - Related articles - BL Direct - All 8 versions

New drugs for the treatment of diabetes: part II: Incretin-based therapy and beyond


SE Inzucchi, DK McGuire - Circulation, 2008 - Am Heart Assoc
This is the second of a 2-part series focusing on newer therapies for type 2
diabetes and their cardiovascular implications. In the first segment, we
reviewed the thiazolidinediones, highlighting emerging data concerning ...
Cited by 22 - Related articles - All 6 versions

Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects …

- diabetesjournals.org
E Muscelli, A Mari, A Casolaro, S Camastra, G … - Diabetes, 2008 - Am Diabetes Assoc
RESEARCH DESIGN AND METHODS—Isoglycemic oral (75 g) and intravenous glucose
administration was performed in 51 subjects (24 with normal glucose tolerance
[NGT], 17 with impaired glucose tolerance [IGT], and 10 with type 2 ...
Cited by 19 - Related articles - BL Direct - All 10 versions

Targeting {beta}-Cell Mass in Type 2 Diabetes: Promise and Limitations of New Drugs Based …

- endojournals.org
M Salehi, BA Aulinger, DA D'Alessio - Endocrine Reviews, 2008 - Endocrine Soc
THE LAST TWO DECADES have seen a major shift in the consensus on the
pathogenesis of type 2 diabetes mellitus (T2DM). Although it is clear that
resistance of peripheral tissues to insulin is an abnormality common to ...
Cited by 13 - Related articles - BL Direct - All 4 versions

Impaired fasting glycaemia vs impaired glucose tolerance: similar impairment of pancreatic …


K Faerch, A Vaag, JJ Holst, C Glümer, O … - Diabetologia, 2008 - Springer
Abstract Aims/hypothesis The impact of strategies for prevention of type 2
diabetes in isolated impaired fasting glycaemia (i-IFG) vs isolated impaired
glucose tolerance (i-IGT) may differ depending on the underlying ...
Cited by 12 - Related articles - BL Direct - All 3 versions

Glucagon-like peptide-1, glucose homeostasis and diabetes


JJ Holst, CF Deacon, T Vilsbøll, T Krarup, S … - Trends in Molecular Medicine, 2008 - Elsevier
Incretins, enhancers of insulin secretion, are essential for glucose tolerance,
and a reduction in their function might contribute to poor β-cell function in
patients with type-2 diabetes mellitus. However, at supraphysiological ...
Cited by 10 - Related articles - All 4 versions

The role of incretins in glucose homeostasis and diabetes treatment

- nih.gov
W Kim, JM Egan - Pharmacological reviews, 2008 - ASPET
Cited by 11 - Related articles - All 5 versions

Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes

- cnam.fr [PDF] 
JF Gautier, SP Choukem, J Girard - Diabetes and Metabolism, 2008 - Elsevier
Incretin hormones are defined as intestinal hormones released in response to
nutrient ingestion, which potentiate the glucose-induced insulin response. In
humans, the incretin effect is mainly caused by two peptide hormones, ...
Cited by 9 - Related articles - All 6 versions

The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and …


FK Knop, T Vilsbøll, PV Højberg, S Larsen, S … - Regulatory Peptides, 2007 - Elsevier
The initial (0–20 min) insulin and C-peptide responses were enhanced
significantly in both groups by GLP-1 and GIP, respectively, compared to saline
(P < 0.05). In both groups GLP-1 infusion resulted in significantly greater ...
Cited by 7 - Related articles - All 4 versions

Reduced Pancreatic Volume and β-Cell Area in Patients With Chronic Pancreatitis


H Schrader, BA Menge, S Schneider, O … - Gastroenterology, 2009 - Elsevier
The pancreatic volumes were 64.9 ± 4.3 cm 3 in CP patients and 82.3 ± 6.7 cm 3
in controls (P = .035). β-cell areas were 0.69% ± 0.08% in CP patients and
0.97% ± 0.08% in controls (P = .017), whereas α-cell areas did not differ ...
Cited by 3 - Related articles - All 36 versions


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