- ►diabetesjournals.org PD Cani, R Bibiloni, C Knauf, A Waget, AM Neyrinck, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—We found that changes of gut microbiota induced by an antibiotic treatment reduced
metabolic endotoxemia and the cecal content of LPS in both high-fat–fed and ob/ob mice. This
effect was correlated with reduced glucose intolerance, body weight gain, fat mass ... Cited by 60 - Related articles - All 5 versions
- ►jbc.org MT Nguyen, S Favelyukis, AK Nguyen, D Reichart, … - Journal of Biological …, 2007 - ASBMB Obesity and type 2 diabetes are characterized by decreased insulin sensitivity, elevated concentrations
of free fatty acids (FFAs), and increased macrophage infiltration in adipose tissue (AT). Here,
we show that FFAs can cause activation of RAW264.7 cells primarily via the JNK ... Cited by 47 - Related articles - All 4 versions
S Schenk, M Saberi, JM Olefsky - The Journal of Clinical …, 2008 - pubmedcentral.nih.gov Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of
a number of diseases, including type 2 diabetes. In this review, we discuss potential mechanisms
by which brief nutrient excess and obesity lead to insulin resistance and propose that ... Cited by 47 - Related articles - All 12 versions
M Zeyda, TM Stulnig - Immunology Letters, 2007 - Elsevier It is now broadly accepted that low-grade chronic inflammation associated with obesity leads
to the onset of insulin resistance and type 2 diabetes mellitus. Obesity-associated inflammation
is characterized by an increased abundance of macrophages in adipose tissue along ... Cited by 34 - Related articles - All 3 versions
LK Heilbronn, LV Campbell - Current Pharmaceutical Design, 2008 - ingentaconnect.com Abstract: Obesity was first described as a low-grade inflammatory condition more than a decade
ago. However, it is only relatively re- cently that obese individuals have been described with
increased macrophage infiltration of adipose tissue, as well as an increase in the number ... Cited by 36 - Related articles - BL Direct - All 2 versions
- ►pnas.org PT Pfluger, D Herranz, S Velasco-Miguel, … - Proceedings of the …, 2008 - National Acad Sciences The identification of new pharmacological approaches to effectively prevent, treat, and cure the
metabolic syndrome is of crucial importance. Excessive exposure to dietary lipids causes inflammatory
responses, deranges the homeostasis of cellular metabolism, and is believed to ... Cited by 36 - Related articles - All 5 versions
- ►physoc.org JR Pauli, ER Ropelle, DE Cintra, MA … - The Journal of …, 2008 - Physiological Soc Early evidence demonstrates that exogenous nitric oxide (NO) and the NO produced by inducible
nitric oxide synthase (iNOS) can induce insulin resistance. Here, we investigated whether this
insulin resistance, mediated by S-nitrosation of proteins involved in early steps of the ... Cited by 16 - Related articles - BL Direct - All 6 versions
- ►ajcn.org J Amar, R Burcelin, JB Ruidavets, PD Cani, J … - American Journal of …, 2008 - Am Soc Nutrition 3 Supported by grants from the Délégation Régionale à la Recherche Clinique des Hôpitaux
de Toulouse 2003, the Institut National de la Santé et de la Recherche Médicale (INSERM), the
Fondation de France, and the Fédération Française de Cardiologie. Cited by 19 - Related articles - BL Direct - All 6 versions
I Wolowczuk, C Verwaerde, O Viltart, A … - Clinical and …, 2008 - pubmedcentral.nih.gov Endogenous intestinal microflora and environmental factors, such as diet, play a central role
in immune homeostasis and reactivity. In addition, microflora and diet both influence body weight
and insulin-resistance, notably through an action on adipose cells. Moreover, it is known ... Cited by 17 - Related articles - All 5 versions
- ►endojournals.org SP Weisberg, R Leibel, DV Tortoriello - Endocrinology, 2008 - Endocrine Soc Obesity is a major risk factor for the development of type 2 diabetes, and both conditions are
now recognized to possess significant inflammatory components underlying their
pathophysiologies. We tested the hypothesis that the plant polyphenolic compound ... Cited by 16 - Related articles - All 4 versions
