JM Oliver-Krasinski, DA Stoffers - Genes & development, 2008 - genesdev.cshlp.org The major forms of diabetes are characterized by pancreatic islet β-cell dysfunction and decreased
β-cell numbers, raising hope for cell replacement therapy. Although human islet transplantation
is a cell-based therapy under clinical investigation for the treatment of type 1 diabetes, the ... Cited by 21 - Related articles - All 4 versions
BM Lyttle, J Li, M Krishnamurthy, F Fellows, MB … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Morphological changes that occur during pancreatic endocrine cell
differentiation have been shown in rodent systems to be dependent on sequential alterations
in transcription factor expression. However, similar data for humans have been limited. ... Cited by 11 - Related articles - BL Direct - All 2 versions
K Docherty, AS Bernardo, L Vallier - Seminars in Cell and Developmental …, 2007 - Elsevier There is a compelling need to develop novel therapies for diabetes mellitus. Recent successes
in the transplantation of islets of Langerhans are seen as a major breakthrough. However, there
is huge disparity between potential recipients and the availability of donor tissue. Human ... Cited by 8 - Related articles - All 2 versions
T Guo, M Hebrok - Endocrine Reviews, 2009 - Endocrine Soc The number of patients worldwide suffering from the chronic disease diabetes mellitus is growing
at an alarming rate. Insulin-secreting β-cells in the islet of Langerhans are damaged to different
extents in diabetic patients, either through an autoimmune reaction present in type 1 ... Cited by 2 - Related articles - All 3 versions
KR Anderson, CA Torres, K Solomon, TC Becker, … - Journal of Biological …, 2009 - ASBMB Nkx2.2 and NeuroD1 are two critical regulators of pancreatic β cell development. Nkx2.2 is a
homeodomain transcription factor that is essential for islet cell type specification and mature
β cell function. NeuroD1 is a basic helix-loop-helix transcription factor that is critical for ... Related articles - All 3 versions
W Guo, C Miao, S Liu, Z Qiu, J Li, E Duan - Cell Proliferation, 2009 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Related articles - All 4 versions