- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis
of diabetes, contributing to pancreatic β-cell loss and insulin resistance. Components of the unfolded
protein response (UPR) play a dual role in β-cells, acting as beneficial regulators under ... Cited by 93 - Related articles - BL Direct - All 5 versions
P Marchetti, M Bugliani, R Lupi, L Marselli, M Masini, U … - Diabetologia, 2007 - Springer Page 1. ARTICLE The endoplasmic reticulum in pancreatic beta cells of type 2
diabetes patients P. Marchetti & M. Bugliani & R. Lupi & L. Marselli & M. Masini &
U. Boggi & F. Filipponi & GC Weir & DL Eizirik & M. Cnop Received ... Cited by 47 - Related articles - BL Direct - All 2 versions
- ►endojournals.org D Scheuner, RJ Kaufman - Endocrine Reviews, 2008 - Endocrine Soc The endoplasmic reticulum (ER) is the entry site into the secretory pathway for newly synthesized
proteins destined for the cell surface or released into the extracellular milieu. The study of protein
folding and trafficking within the ER is an extremely active area of research that has ... Cited by 38 - Related articles - BL Direct - All 5 versions
- ►endojournals.org L Haataja, T Gurlo, CJ Huang, PC Butler - Endocrine Reviews, 2008 - Endocrine Soc Type 2 diabetes (T2DM) is characterized by insulin resistance, defective insulin secretion, loss
of β-cell mass with increased β-cell apoptosis and islet amyloid. The islet amyloid is derived
from islet amyloid polypeptide (IAPP, amylin), a protein coexpressed and cosecreted with ... Cited by 28 - Related articles - BL Direct - All 4 versions
- ►biologists.org DA Cunha, P Hekerman, L Ladriere, A Bazarra- … - Journal of cell …, 2008 - jcs.biologists.org Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might contribute to β-cell loss
in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied here the
molecular mechanisms implicated in FFA-induced ER stress initiation and apoptosis in ... Cited by 23 - Related articles - All 5 versions
B Song, D Scheuner, D Ron, S Pennathur, … - The Journal of …, 2008 - pubmedcentral.nih.gov The progression from insulin resistance to type 2 diabetes is caused by the failure of pancreatic
β cells to produce sufficient levels of insulin to meet the metabolic demand. Recent studies indicate
that nutrient fluctuations and insulin resistance increase proinsulin synthesis in β cells ... Cited by 23 - Related articles - All 7 versions
- ►geyseco.info [PDF] JJ Meier - Diabetologia, 2008 - Springer Abstract Beta cell deficiency underlies both type 1 and type 2 diabetes, and restoration or replacement
of beta cell function is therefore the logical long-term solution to therapy. This review sets out
to describe the defects in beta cell mass and function in both forms of diabetes, summa- ... Cited by 16 - Related articles - BL Direct - All 6 versions
K Aston-Mourney, J Proietto, G Morahan, S … - Diabetologia, 2008 - Springer Abstract In many countries, first- or second-line pharma- cological treatment of patients with type
2 diabetes consists of sulfonylureas (such as glibenclamide [known as glyburide in the USA
and Canada]), which stimulate the beta cell to secrete insulin. However, emerging ... Cited by 12 - Related articles - BL Direct - All 3 versions
KJ Chang-Chen, R Mullur, E Bernal-Mizrachi - Reviews in Endocrine & …, 2008 - Springer Abstract Type 2 diabetes mellitus is a complex disease characterized by b-cell failure in the setting
of insulin resistance. In early stages of the disease, pancreatic b-cells adapt to insulin resistance
by increasing mass and function. As nutrient excess persists, hyperglycemia and elevated ... Cited by 12 - Related articles - All 2 versions
M Cnop - Biochemical Society Transactions, 2008 - biochemsoctrans.org The prevalence of Type 2 diabetes is increasing dramatically as a result of the obesity
epidemic, and poses a major health and socio-economic burden. Type 2 diabetes develops
in individuals who fail to compensate for insulin resistance by increasing pancreatic ... Cited by 10 - Related articles - Cached - BL Direct - All 4 versions
